非H2抗原的检测，这些抗原与Ia抗原一样，与B淋巴细胞的Fc受体相关。
Detection of non-H2 antigen(s) which, like Ia antigens, are associated with the Fc receptor of B lymphocytes.
作者信息
Dickler H B, Cone J L, Kubicek M T, Sachs D H
出版信息
J Exp Med. 1975 Sep 1;142(3):796-801. doi: 10.1084/jem.142.3.796.
Abstract
Antibodies contained in an A/J anti-B10 antiserum, when tested on lymphocytes from B10.A mice, were shown to bind to both B and T cells and to inhibit the binding of Ig complexes to the Fc receptors of B lymphocytes. These antibodies could be removed by absorption with B10.D2 lymphocytes. Similar results were obtained with lymphocytes from two to six (B6A)F1 x A/J backcross mice which had H-2a/a genotype. These data indicate that alloantigens determined by at least one non-H-2 locus are associated with or a part of Fc receptors. These antigens may be similar in structure and function to Ia antigens.
摘要
当用A/J抗B10抗血清中的抗体检测B10.A小鼠的淋巴细胞时，发现这些抗体既能与B细胞结合，也能与T细胞结合，并能抑制Ig复合物与B淋巴细胞Fc受体的结合。这些抗体可以用B10.D2淋巴细胞吸收去除。用具有H-2a/a基因型的两到六只（B6A）F1×A/J回交小鼠的淋巴细胞也得到了类似结果。这些数据表明，至少一个非H-2基因座所决定的同种抗原与Fc受体相关或为Fc受体的一部分。这些抗原在结构和功能上可能与Ia抗原相似。
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Detection of non-H2 antigen(s) which, like Ia antigens, are associated with the Fc receptor of B lymphocytes.非H2抗原的检测，这些抗原与Ia抗原一样，与B淋巴细胞的Fc受体相关。
J Exp Med. 1975 Sep 1;142(3):796-801. doi: 10.1084/jem.142.3.796.
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Evidence for identity or close association of the Fc receptor of B lymphocytes and alloantigens determined by the Ir region of the H-2 complex.关于B淋巴细胞的Fc受体与由H-2复合体的Ir区域所决定的同种异体抗原的同一性或紧密关联的证据。
J Exp Med. 1974 Sep 1;140(3):779-96. doi: 10.1084/jem.140.3.779.
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B-lymphocyte Fc receptor-associated non-H-2 antigens are determined by a single polymorphic locus which is linked to the Mls locus.B淋巴细胞Fc受体相关非H-2抗原由一个与Mls基因座连锁的单态性基因座决定。
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Interactions of Fc receptors with antibodies against Ia antigens and other cell surface components.Fc受体与抗Ia抗原及其他细胞表面成分抗体的相互作用。
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Relationship between Fc receptors, antigen-binding sites on T and B cells, and H-2 complex-associated determinants.Fc受体、T细胞和B细胞上的抗原结合位点与H-2复合体相关决定簇之间的关系。
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The Fc receptor on thymus-derived lymphocytes. IV. Inhibition of binding of antigen-antibody complexes to Fc receptor-positive T cells by anti-Ia sera.胸腺来源淋巴细胞上的Fc受体。IV. 抗Ia血清对抗原-抗体复合物与Fc受体阳性T细胞结合的抑制作用。
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Association between Ia antigens and the Fc receptors of certain T lymphocytes.某些T淋巴细胞的Ia抗原与Fc受体之间的关联。
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B-lymphocyte Fc receptor-associated non-H-2 antigens are determined by a single polymorphic locus which is linked to the Mls locus.B淋巴细胞Fc受体相关非H-2抗原由一个与Mls基因座连锁的单态性基因座决定。
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J Exp Med. 1977 Jan 1;145(1):187-203. doi: 10.1084/jem.145.1.187.
本文引用的文献
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Arch Biochem Biophys. 1960 Aug;89:230-44. doi: 10.1016/0003-9861(60)90049-7.
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A receptor for antibody on B lymphocytes. I. Method of detection and functional significance.B淋巴细胞上的抗体受体。I. 检测方法及功能意义。
J Exp Med. 1972 Mar 1;135(3):610-26. doi: 10.1084/jem.135.3.610.
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Strain C57BL-10ScSn and its congenic resistant sublines.C57BL - 10ScSn品系及其同源抗性亚系。
Transplant Proc. 1970 Mar;2(1):39-47.
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The genetic control of antibody specificity.抗体特异性的遗传控制。
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Evidence for identity or close association of the Fc receptor of B lymphocytes and alloantigens determined by the Ir region of the H-2 complex.关于B淋巴细胞的Fc受体与由H-2复合体的Ir区域所决定的同种异体抗原的同一性或紧密关联的证据。
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6
A mouse B-cell alloantigen determined by gene(s) linked to the major histocompatibility complex.一种由与主要组织相容性复合体连锁的基因所决定的小鼠B细胞同种抗原。
J Exp Med. 1973 Dec 1;138(6):1289-304. doi: 10.1084/jem.138.6.1289.
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Interaction of aggregated -globulin with B lymphocytes.聚集的γ球蛋白与B淋巴细胞的相互作用。
J Exp Med. 1972 Jul 1;136(1):191-6. doi: 10.1084/jem.136.1.191.
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Transplant Proc. 1975 Mar;7(1):123-9.
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Interactions of Fc receptors with antibodies against Ia antigens and other cell surface components.Fc受体与抗Ia抗原及其他细胞表面成分抗体的相互作用。
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The possible role of i region determined cell surface molecules in the regulation of immune responses.I区决定的细胞表面分子在免疫反应调节中的可能作用。
Transplant Rev. 1975;23:159-75. doi: 10.1111/j.1600-065x.1975.tb00156.x.
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