Dickler H B, Cone J L, Kubicek M T, Sachs D H
J Exp Med. 1975 Sep 1;142(3):796-801. doi: 10.1084/jem.142.3.796.
Antibodies contained in an A/J anti-B10 antiserum, when tested on lymphocytes from B10.A mice, were shown to bind to both B and T cells and to inhibit the binding of Ig complexes to the Fc receptors of B lymphocytes. These antibodies could be removed by absorption with B10.D2 lymphocytes. Similar results were obtained with lymphocytes from two to six (B6A)F1 x A/J backcross mice which had H-2a/a genotype. These data indicate that alloantigens determined by at least one non-H-2 locus are associated with or a part of Fc receptors. These antigens may be similar in structure and function to Ia antigens.
当用A/J抗B10抗血清中的抗体检测B10.A小鼠的淋巴细胞时，发现这些抗体既能与B细胞结合，也能与T细胞结合，并能抑制Ig复合物与B淋巴细胞Fc受体的结合。这些抗体可以用B10.D2淋巴细胞吸收去除。用具有H-2a/a基因型的两到六只（B6A）F1×A/J回交小鼠的淋巴细胞也得到了类似结果。这些数据表明，至少一个非H-2基因座所决定的同种抗原与Fc受体相关或为Fc受体的一部分。这些抗原在结构和功能上可能与Ia抗原相似。
