Wallenhammar L M, Ortengren U, Andreasson H, Barregård L, Björkner B, Karlsson S, Wrangsjö K, Meding B
Occupational Dermatology, National Institute for Working Life, Stockholm, Sweden.
Contact Dermatitis. 2000 Oct;43(4):192-9. doi: 10.1034/j.1600-0536.2000.043004192.x.
Hand eczema and contact allergy in Swedish dentists were studied in a multidisciplinary project. The aims of the study were to establish diagnoses, to investigate the occurrence of contact allergy, in particular to (meth)acrylates, and to evaluate certain consequences of hand eczema. A postal questionnaire on skin symptoms, atopy and occupational experience was mailed to 3,500 dentists aged <65 years, and licensed 1965-1995. The response rate was 88%. Among dentists living in 3 major cities, 14.9% (n= 191) reported hand eczema during the previous year. They were invited to a clinical examination, including patch testing with a standard and a dental series. 158/191 (83%) dentists attended, and hand eczema diagnosis was confirmed in 149/158 (94%). Irritant contact dermatitis was diagnosed in 67% and allergic contact dermatitis in 28%. On patch testing, 50% presented at least 1 positive reaction. The most frequent allergens were nickel sulfate, fragrance mix, gold sodium thiosulfate and thiuram mix. 7 (5%) had positive reactions to (meth)acrylates, all to 2-hydroxyethyl methacrylate and 6 also to ethyleneglycol dimethacrylate. 38% had consulted a physician, 4% had been on sick-leave and 1% had changed occupational tasks due to hand eczema. No dentist with allergy to acrylates had been on sick-leave or changed occupation. It is concluded that dentistry is a high-risk occupation for hand eczema, and that irritant contact dermatitis is most common. The prevalence of contact allergy to acrylates was below 1% in the population of responding dentists, and in most cases did not have serious medical, social or occupational consequences.
在一个多学科项目中对瑞典牙医的手部湿疹和接触性过敏进行了研究。该研究的目的是进行诊断,调查接触性过敏尤其是对(甲基)丙烯酸酯类的发生率,并评估手部湿疹的某些后果。向3500名年龄小于65岁且于1965年至1995年获得执照的牙医邮寄了一份关于皮肤症状、特应性和职业经历的邮政问卷。回复率为88%。在居住于3个主要城市的牙医中,14.9%(n = 191)报告在前一年有手部湿疹。他们被邀请进行临床检查,包括使用标准系列和牙科系列进行斑贴试验。191名牙医中有158名(83%)参加了检查,158名中的149名(94%)手部湿疹诊断得到确认。刺激性接触性皮炎诊断率为67%,过敏性接触性皮炎为28%。在斑贴试验中,50%至少有1次阳性反应。最常见的变应原是硫酸镍、香料混合物、硫代硫酸金钠和秋兰姆混合物。7名(5%)对(甲基)丙烯酸酯类有阳性反应,均对甲基丙烯酸2 - 羟乙酯有反应,6名对乙二醇二甲基丙烯酸酯也有反应。38%曾咨询过医生,4%曾休病假,1%因手部湿疹改变了职业任务。对丙烯酸酯类过敏的牙医无人休病假或改变职业。结论是牙科是手部湿疹的高风险职业,且刺激性接触性皮炎最为常见。在回复问卷的牙医群体中,对丙烯酸酯类接触过敏的患病率低于1%,且在大多数情况下没有严重的医学、社会或职业后果。