Reiss D, Neiderhiser J M
Department of Psychiatry and Behavorial Sciences, The George Washington University,Washington, DC 20037, USA.
Dev Psychopathol. 2000 Summer;12(3):357-74. doi: 10.1017/s0954579400003060.
In the coming years we can look forward to research that clarifies specific mechanisms that account for the interplay between genetic and environmental influences on psychological development. Certain misconceptions, arising from research traditions initiated by Francis Galton on the one hand and G. Stanley Hall on the other, may now be set aside in the light of new evidence. Three important findings promise a new synthesis. First, while each of us is born with about 100,000 genes that, under ordinary circumstances, do not change, the expression of these genes on behavior is dynamic. Some genetic influences are expressed early in development, but others are manifest many years later. Second, genetic factors often account not only for some of the individual differences in the measures of adjustments we typically use to monitor development but also for individual differences in environmental experiences that covary with those measures of adjustment. Indeed, genetic factors have been found to account for a surprising amount of covariance between measures of the social environment and of adjustment in young children, adolescents, and adults. Third, the expression of genetic influences are very malleable and responsive to the social environment. These new findings are revealing specific mechanisms for the interplay of genetic and social environmental factors in four domains. First, the social environment may play both a necessary and specific role in the expression of particular genetic influences on a range of behaviors from depression to social responsibility. Second, an understanding of the interplay between the social environment and genetics may lead to a clearer definition of the phenotypic manifestations of particular genetic influences. Third, we will-as a result of these studies-have a clearer fix on the timing of important events and their sequence in development. Fourth, this new genre of work promises to illumine more completely mechanisms by which the social environment influences development independent of genetic influence.
在未来几年,我们有望看到一些研究,这些研究将阐明基因和环境对心理发展的相互影响所涉及的具体机制。某些因弗朗西斯·高尔顿和G. 斯坦利·霍尔开创的研究传统而产生的误解,现在可能会根据新证据而被搁置一旁。三项重要发现有望带来新的综合。首先,虽然我们每个人生来都有大约10万个基因,在正常情况下这些基因不会改变,但这些基因在行为上的表达是动态的。一些基因影响在发育早期就会表现出来,但其他影响则在多年后才显现。其次,基因因素不仅常常导致我们通常用来监测发展的调适测量中的一些个体差异,还导致与这些调适测量相关的环境经历中的个体差异。事实上,已经发现基因因素在幼儿、青少年和成年人的社会环境测量与调适测量之间的协方差中占了惊人的比例。第三,基因影响的表达具有很强的可塑性,并且对社会环境有反应。这些新发现揭示了基因和社会环境因素在四个领域相互作用的具体机制。首先,社会环境可能在特定基因对从抑郁到社会责任等一系列行为的影响的表达中既起到必要作用又起到特定作用。其次,对社会环境与基因之间相互作用的理解可能会使我们对特定基因影响的表型表现有更清晰的定义。第三,由于这些研究,我们将更清楚地确定重要事件的时间及其在发育中的顺序。第四,这类新的研究有望更全面地阐明社会环境独立于基因影响而影响发展的机制。