Sedgh G, Herrera M G, Nestel P, el Amin A, Fawzi W W
Departments of. Epidemiology and. Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
J Nutr. 2000 Oct;130(10):2520-6. doi: 10.1093/jn/130.10.2520.
We examined prospectively the associations between dietary vitamin A intake, nondietary factors and growth in 8174 Sudanese children ages 6-72 mo who were stunted at the start of follow-up. All subjects were weighed and measured at baseline and at 6-mo intervals for 18 mo of follow-up. Dietary vitamin A intake during the prior 24 h was assessed using recall of vitamin A-containing foods at baseline and 6-mo intervals. We examined the association of dietary vitamin A intake with growth and the incidence of recovery of stunting after controlling for age, sex, breast-feeding status and socioeconomic variables. We found that carotenoid intake was associated with a greater incidence of reversal of stunting. Children in the highest quintile grew 13 mm more during the study period than children in the lowest quintile [95% confidence interval (CI): 0-25 mm] in multivariate analyses. The relative risk (RR) of recovery associated with vitamin A intake was greater in infants up to 1 y old (RR = 3.3, CI: 0.9-11.7) than in children > or =3 y of age (RR = 1.0, CI: 0.8-1. 3) (P:-value for interaction = 0.08). Diets rich in carotenoids may increase the rate of recovery from stunting in children. Dietary effects on growth might be strongest among very young children and those who have been most malnourished. Age, sex, breast-feeding status, socioeconomic status and severity of baseline stunting also were associated with reversal of stunting in this population.
我们对8174名6至72月龄的苏丹儿童进行了前瞻性研究，这些儿童在随访开始时发育迟缓。在随访的18个月中，所有受试者在基线时以及每隔6个月进行一次体重和身高测量。通过回忆基线时和每隔6个月摄入含维生素A食物的情况，评估前24小时的膳食维生素A摄入量。在控制年龄、性别、母乳喂养状况和社会经济变量后，我们研究了膳食维生素A摄入量与生长以及发育迟缓恢复发生率之间的关联。我们发现类胡萝卜素摄入量与发育迟缓逆转的发生率较高有关。在多变量分析中，最高五分位数组的儿童在研究期间比最低五分位数组的儿童多生长13毫米[95%置信区间（CI）：0 - 25毫米]。1岁以下婴儿维生素A摄入量相关的恢复相对风险（RR）（RR = 3.3，CI：0.9 - 11.7）高于3岁及以上儿童（RR = 1.0，CI：0.8 - 1.3）（交互作用P值 = 0.08）。富含类胡萝卜素的饮食可能会提高儿童发育迟缓的恢复率。饮食对生长的影响可能在非常年幼的儿童和营养不良最严重的儿童中最为明显。年龄、性别、母乳喂养状况、社会经济地位以及基线发育迟缓的严重程度也与该人群发育迟缓的逆转有关。
