Weinans M J, Huijssoon A M, Tymstra T, Gerrits M C, Beekhuis J R, Mantingh A
Antenatal Diagnosis Unit, Department of Obstetrics and Gynaecology, University Hospital Groningen, The Netherlands.
Prenat Diagn. 2000 Sep;20(9):705-8. doi: 10.1002/1097-0223(200009)20:9<705::aid-pd904>3.0.co;2-c.
To gain insight into how pregnant women experience serum screening for Down syndrome, we sent questionnaires to two groups of relevant subjects in the north of the Netherlands. The questionnaires addressed the following issues: decision-making process, knowledge and opinions. Questionnaire A was sent to women of 36 years of age and older (n=99) (group A) who were all 20 to 36 weeks pregnant at that time. In the Netherlands prenatal diagnosis is routinely available to these women. Questionnaire B was sent to women of younger than 36 years (n=69) (group B) who had received a screen-positive result and had subsequently undergone amniocentesis. About half of these women were still pregnant at that time. For these women, serum screening is only available on the basis of opting-in. The two questionnaires were largely identical. The response rates to questionnaires A and B were 82% and 91%, respectively. Group A (women of 36 years and older) considered that second trimester serum screening made a welcome contribution to the decision-making process about whether to undergo amniocentesis. Moreover, it reduced the amniocentesis rate considerably. The vast majority said they would apply for serum screening in a following pregnancy, but favoured the idea of first trimester screening. In group B (women of younger than 36 years), reassurance was the most commonly mentioned reason for undergoing serum screening. Almost all the women experienced some degree of anxiety when they were informed about the screen-positive result and 13% continued to be anxious, even after the favourable result of the amniocentesis. The majority of the respondents would also apply for serum screening in a following pregnancy and were of the opinion that this screening should be offered to all pregnant women in the Netherlands.
为深入了解孕妇对唐氏综合征血清筛查的体验，我们向荷兰北部的两组相关受试者发放了问卷。问卷涉及以下问题：决策过程、知识和观点。问卷A发放给了36岁及以上的女性（n = 99）（A组），她们当时均处于怀孕20至36周。在荷兰，这些女性可常规进行产前诊断。问卷B发放给了年龄小于36岁的女性（n = 69）（B组），她们的筛查结果为阳性，随后接受了羊水穿刺术。当时，这些女性中约一半仍处于孕期。对于这些女性，血清筛查仅在选择加入的基础上提供。两份问卷基本相同。问卷A和问卷B的回复率分别为82%和91%。A组（36岁及以上的女性）认为孕中期血清筛查对是否进行羊水穿刺术的决策过程有很大帮助。此外，它显著降低了羊水穿刺术的比率。绝大多数人表示她们会在下次怀孕时申请血清筛查，但更倾向于孕早期筛查的想法。在B组（年龄小于36岁的女性）中，安心是进行血清筛查最常提到的原因。几乎所有女性在得知筛查结果为阳性时都经历了一定程度的焦虑，即使羊水穿刺术结果良好，仍有13%的女性持续焦虑。大多数受访者也会在下次怀孕时申请血清筛查，并认为这种筛查应该提供给荷兰所有孕妇。
