Yoshimura H, Yoshihara S, Ozawa N, Miki M
Ann N Y Acad Sci. 1979 May 31;320:179-92. doi: 10.1111/j.1749-6632.1979.tb56600.x.
Acute toxicity of individual PCBs, which were categorized as either phenobarbital (PB)- or 3-methylcholanthrene (MC)-type inducers, was examined in young male Wistar rats, comparing their effects on growth rate, organ weight and liver lipid content, 5 days after a single i.p. injection. PB-type PCBs (2,4,3',4'- and 2,5,2'5'-tetrachlorobiphenyl), which slightly increased a content of cytochrome P450, did not show any significant toxicity at a dose of 100 mg/kg. On the contrary, MC-type PCBs (3,4,5,3',4'-pentachloro- and 3,4,5,3',4',5'-hexachlorobiphenyl), which markedly increased a content of cytochrome P448, strongly reduced growth rate and weights of thymus and spleen at a dose of 10 mg/kg. Liver enlargement accompanied by fatty liver was also observed only with MC-type PCBs. 3,4,3',4'-Tetrachlorobiphenyl was also toxic at a dose of 50 mg/kg, in keeping with its weak MC-type-inducing ability. Pretreatment with MC affected neither growth rate, spleen weight, nor liver lipid content. These results suggest that the toxic potency of PCBs is related to their MC-type inducing ability, but the toxic characteristics are different from those of MC itself.
在年轻雄性Wistar大鼠中检测了分别归类为苯巴比妥（PB）型或3 - 甲基胆蒽（MC）型诱导剂的各多氯联苯（PCBs）的急性毒性，比较了单次腹腔注射5天后它们对生长速率、器官重量和肝脏脂质含量的影响。PB型多氯联苯（2,4,3',4'-和2,5,2'5'-四氯联苯），其可使细胞色素P450含量略有增加，在剂量为100 mg/kg时未显示任何明显毒性。相反，MC型多氯联苯（3,4,5,3',4'-五氯联苯和3,4,5,3',4',5'-六氯联苯），其可显著增加细胞色素P448含量，在剂量为10 mg/kg时强烈降低生长速率以及胸腺和脾脏的重量。仅在MC型多氯联苯处理组中观察到伴有脂肪肝的肝脏肿大。3,4,3',4'-四氯联苯在剂量为50 mg/kg时也具有毒性，这与其较弱的MC型诱导能力相符。用MC预处理对生长速率、脾脏重量或肝脏脂质含量均无影响。这些结果表明，多氯联苯的毒性效力与其MC型诱导能力有关，但其毒性特征与MC本身不同。
