Arvand M, Hoeck M, Hahn H, Wagner J
Institut für Infektionsmedizin, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Germany.
J Antimicrob Chemother. 2000 Oct;46(4):621-4. doi: 10.1093/jac/46.4.621.
A total of 212 clinical Streptococcus pyogenes isolates were tested for susceptibility to various antibiotics by agar dilution. The overall frequency of erythromycin resistance was 12.7%, being higher in isolates from children (18.9%) than in those from adult patients (10.7%). Similar results were found for clarithromycin, while 2.8% of the isolates were resistant to ciprofloxacin. All strains were susceptible to penicillin and cefotaxime. Of the erythromycin-resistant isolates subjected to the double-disc diffusion test for erythromycin and clindamycin, 35% expressed constitutive and 55% inducible resistance to clindamycin. Ten per cent were susceptible to clindamycin (M-phenotype). Thus, a high rate of macrolide resistance in S. pyogenes has emerged in Berlin.
通过琼脂稀释法对总共212株临床分离的化脓性链球菌进行了多种抗生素敏感性测试。红霉素耐药的总体发生率为12.7%，儿童分离株中的发生率（18.9%）高于成年患者分离株（10.7%）。克拉霉素的结果相似，而2.8%的分离株对环丙沙星耐药。所有菌株对青霉素和头孢噻肟敏感。在对红霉素和克林霉素进行双碟扩散试验的红霉素耐药分离株中，35%表现为对克林霉素的组成型耐药，55%表现为诱导型耐药。10%对克林霉素敏感（M表型）。因此，柏林出现了化脓性链球菌中较高的大环内酯耐药率。
