Bowd C, Weinreb R N, Lee B, Emdadi A, Zangwill L M
Glaucoma Center and Diagnostic Imaging Laboratory, Department of Ophthalmology, University of California, San Diego, La Jolla, California 92093-0946, USA.
Am J Ophthalmol. 2000 Sep;130(3):280-6. doi: 10.1016/s0002-9394(00)00488-8.
We examined changes in optic disk topography using confocal scanning laser ophthalmoscopy after reducing intraocular pressure with administration of latanoprost.
Twenty-nine patients with glaucoma or ocular hypertension were imaged using the Heidelberg Retina Tomograph before and after the administration of latanoprost to decrease intraocular pressure. Average time between pretreatment and posttreatment imaging was 2.7 +/- 1.8 weeks. Heidelberg Retina Tomograph software-measured parameters were mean height of contour, cup area, cup volume, mean cup depth, maximum cup depth, cup shape, rim area, rim volume, cup-to-disk ratio, and retinal nerve fiber thickness.
Average intraocular pressure decreased significantly (mean +/- SD) by 7.2 +/- 5.4 mm Hg (25 +/- 16% decrease). No statistically significant changes in measured topographic parameters were found. When data from patients with decreases in intraocular pressure of 7 mm Hg or greater were analyzed separately (mean intraocular pressure decrease = 10.79 +/- 4.32 mm Hg, 36 +/- 8% decrease), cup area (P =.005), cup volume (P =. 002), and cup-to-disk ratio (P =.005) decreased significantly, and rim area (P =.005) increased significantly. Linear regression analysis of the data from all subjects showed that a change in intraocular pressure after latanoprost administration accounted for 12% or more of the variance in two measured topographic parameters (mean cup depth and cup shape).
These results suggest that, in some patients, moderate decreases in intraocular pressure may affect disk topography, as measured by Heidelberg Retina Tomograph. Intraocular pressure should be considered when analyzing consecutive confocal scanning laser ophthalmoscopy images for glaucomatous progression.
我们使用共焦扫描激光眼底镜检查了在使用拉坦前列素降低眼压后视盘地形图的变化。
对29例青光眼或高眼压症患者在使用拉坦前列素降低眼压前后使用海德堡视网膜断层扫描仪进行成像。治疗前和治疗后成像之间的平均时间为2.7±1.8周。海德堡视网膜断层扫描仪软件测量的参数包括轮廓平均高度、杯盘面积、杯盘容积、平均杯盘深度、最大杯盘深度、杯盘形状、盘沿面积、盘沿容积、杯盘比和视网膜神经纤维厚度。
平均眼压显著降低（均值±标准差）7.2±5.4 mmHg（降低25±16%）。未发现测量的地形参数有统计学显著变化。当单独分析眼压降低7 mmHg或更多的患者的数据时（平均眼压降低 = 10.79±4.32 mmHg，降低36±8%），杯盘面积（P = 0.005）、杯盘容积（P = 0.002）和杯盘比（P = 0.005）显著降低，盘沿面积（P = 0.005）显著增加。对所有受试者的数据进行线性回归分析表明，使用拉坦前列素后眼压的变化占两个测量地形参数（平均杯盘深度和杯盘形状）方差的12%或更多。
这些结果表明，在一些患者中，眼压的适度降低可能会影响通过海德堡视网膜断层扫描仪测量的视盘地形图。在分析连续的共焦扫描激光眼底镜图像以评估青光眼进展时应考虑眼压因素。
