Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Invest Ophthalmol Vis Sci. 2024 Jul 1;65(8):48. doi: 10.1167/iovs.65.8.48.
The purpose of this study was to investigate the effect of globe and optic nerve (ON) morphologies and tissue stiffnesses on gaze-induced optic nerve head deformations using parametric finite element modeling and a design of experiment (DOE) approach.
A custom software was developed to generate finite element models of the eye using 10 morphological parameters: dural radius, scleral, choroidal, retinal, pial and peripapillary border tissue thicknesses, prelaminar tissue depth, lamina cribrosa (LC) depth, ON radius, and ON tortuosity. A central composite face-centered design (1045 models) was used to predict the effects of each morphological factor and their interactions on LC strains induced by 13 degrees of adduction. Subsequently, a further DOE analysis (1045 models) was conducted to study the effects and potential interactions between the top five morphological parameters identified from the initial DOE study and five critical tissue stiffnesses.
In the DOE analysis of 10 morphological parameters, the 5 most significant factors were ON tortuosity, dural radius, ON radius, scleral thickness, and LC depth. Further DOE analysis incorporating biomechanical parameters highlighted the importance of dural and LC stiffness. A larger dural radius and stiffer dura increased LC strains but the other main factors had the opposite effects. Notably, the significant interactions were found between dural radius with dural stiffness, ON radius, and ON tortuosity.
This study highlights the significant impact of morphological factors on LC deformations during eye movements, with key morphological effects being more pronounced than tissue stiffnesses.
本研究旨在通过参数有限元建模和实验设计（DOE）方法，研究眼球和视神经（ON）形态及组织硬度对视神经头变形的影响。
开发了一种定制软件，使用 10 个形态学参数生成眼球的有限元模型：硬脑膜半径、巩膜、脉络膜、视网膜、软脑膜和视盘边缘组织厚度、前层组织深度、筛板（LC）深度、视神经半径和视神经扭曲度。采用中心复合面心设计（1045 个模型）预测每个形态学因素及其相互作用对 13 度内收引起的 LC 应变的影响。随后，进行了进一步的 DOE 分析（1045 个模型），研究了从初始 DOE 研究中确定的前五个形态学参数和五个关键组织硬度之间的影响和潜在相互作用。
在 10 个形态学参数的 DOE 分析中，前 5 个最重要的因素是视神经扭曲度、硬脑膜半径、视神经半径、巩膜厚度和 LC 深度。进一步结合生物力学参数的 DOE 分析强调了硬脑膜和 LC 硬度的重要性。更大的硬脑膜半径和更硬的硬脑膜会增加 LC 应变，但其他主要因素则相反。值得注意的是，在硬脑膜半径与硬脑膜硬度、视神经半径和视神经扭曲度之间发现了显著的相互作用。
本研究强调了形态学因素对视神经头在眼球运动过程中变形的显著影响，关键形态学效应比组织硬度更为明显。
