Irak I, Zangwill L, Garden V, Shakiba S, Weinreb R N
Glaucoma Center and Research Laboratories, University of California, San Diego 92093-0946, USA.
Am J Ophthalmol. 1996 Nov;122(5):690-5. doi: 10.1016/s0002-9394(14)70488-x.
To investigate the relationship between optic disk topography and intraocular pressure before and after trabeculectomy with confocal scanning laser ophthalmoscopy.
The eyes of 49 consecutive patients undergoing trabeculectomy at a university-based glaucoma practice underwent preoperative and postoperative imaging using a confocal scanning laser ophthalmoscope (Heidelberg Retina Tomograph). Three images of one eye of each patient were obtained with a 15-degree field of view. Preoperative images were obtained approximately 2 months before surgery (mean +/- SD, 2.4 +/- 1.6 months). Postoperative images were obtained at least 3 months after surgery (mean, 4.5 +/- 2.6 months).
Mean preoperative intraocular pressure, postoperative intraocular pressure, and percent change in intraocular pressure respectively were 23.1 +/- 6.8 mm Hg, 12.7 +/- 7.1 mm Hg, and 43.8% +/- 29.9%. A significant association (P < .01) was found between percent decrease in intraocular pressure and decreases in cup area, cup volume, and cup/disk area ratio as well as between percent decrease in intraocular pressure and increases in rim area, rim volume, mean height contour, retinal cross-section area, and height in contour. Between 11.7% and 31.2% of the variability (R2) in these parameters was explained by the percent change in intraocular pressure. Topography changes were more strongly associated with percent change than with mean change in intraocular pressure. We found no association between percent decrease in intraocular pressure and reference plane height or maximum cup depth.
Changes in optic nerve topography were associated with reduction in intraocular pressure after trabeculectomy.
采用共焦扫描激光眼底镜研究小梁切除术前、后视盘地形图与眼压之间的关系。
在一所大学的青光眼诊所，对49例连续接受小梁切除术的患者的眼睛，使用共焦扫描激光眼底镜（海德堡视网膜断层扫描仪）进行术前和术后成像。以15度视野获取每位患者一只眼睛的三张图像。术前图像在手术前约2个月获取（平均±标准差，2.4±1.6个月）。术后图像在手术后至少3个月获取（平均，4.5±2.6个月）。
术前平均眼压、术后平均眼压及眼压变化百分比分别为23.1±6.8 mmHg、12.7±7.1 mmHg和43.8%±29.9%。眼压降低百分比与杯盘面积、杯盘容积及杯盘面积比的降低之间，以及眼压降低百分比与视盘边缘面积、视盘边缘容积、平均高度轮廓、视网膜横截面积及轮廓高度的增加之间，均存在显著相关性（P<0.01）。这些参数中11.7%至31.2%的变异性（R2）可由眼压变化百分比来解释。地形图变化与眼压变化百分比的相关性，比与眼压平均变化的相关性更强。我们发现眼压降低百分比与参考平面高度或最大杯盘深度之间无相关性。
小梁切除术后视神经地形图的变化与眼压降低相关。
