Zhao D, Tomono Y, Tsuboi K, Nose T
Department of Neurosurgery, University of Tsukuba, Ibaraki.
Neurol Med Chir (Tokyo). 2000 Sep;40(9):453-6; discussion 456-7. doi: 10.2176/nmc.40.453.
Sixty-five clinically nonfunctioning pituitary adenomas were studied by immunohistochemistry, and 12 cases were also analyzed by electron microscopy. Thirty-nine cases (60%) were immunohistochemically identified as hormone-producing adenomas. Six adenomas produced multiple hormones. Electron microscopy found seven null cell adenomas and five oncocytomas. The oncocytomas had a significantly higher incidence of hormone expression that the null cell adenomas. These results indicate that clinically nonfunctioning pituitary adenomas produce hormones, even though blood hormone levels are normal or low. Furthermore, the evidence of multihormonal production implies that two or more cell lineages including a protein hormone-producing type and a glycoprotein hormone-producing type may exist in the same nonfunctioning pituitary adenoma.
通过免疫组织化学对65例临床无功能垂体腺瘤进行了研究，其中12例还进行了电子显微镜分析。39例（60%）经免疫组织化学鉴定为分泌激素的腺瘤。6例腺瘤分泌多种激素。电子显微镜发现7例无分泌颗粒细胞腺瘤和5例嗜酸细胞瘤。嗜酸细胞瘤激素表达的发生率明显高于无分泌颗粒细胞腺瘤。这些结果表明，临床无功能垂体腺瘤即使血液激素水平正常或偏低也会分泌激素。此外，多激素分泌的证据意味着在同一个无功能垂体腺瘤中可能存在两种或更多种细胞谱系，包括分泌蛋白质激素的细胞谱系和分泌糖蛋白激素的细胞谱系。
