Sazonova E N, Yakovenko I G, Kryzhanovskaya S Yu, Budylev A A, Timoshin S S
Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk, Russia.
Bull Exp Biol Med. 2012 Jan;152(3):304-6. doi: 10.1007/s10517-012-1514-1.
DNA-synthetic activity of myocardial cells was studied by (3)H-thymidine autoradiography in newborn albino rats after intraperitoneal injection of hydra peptide morphogen and its analogues. Administration of hydra peptide morphogen stimulated proliferative activity in the myocardium. Short analogues of hydra peptide morphogen, 6C and 3C peptides, produced a similar effect. Administration of arginine-containing analogue of hydra peptide morphogen significantly reduced the number of DNA-synthesizing nuclei in the ventricular myocardium of newborn albino rats. The role of the structure of the peptide molecule in the realization of the morphogenetic effects of hydra peptide morphogen is discussed.
在新生白化大鼠腹腔注射水螅肽形态发生原及其类似物后，通过（3）H-胸腺嘧啶核苷放射自显影术研究心肌细胞的DNA合成活性。水螅肽形态发生原的给药刺激了心肌中的增殖活性。水螅肽形态发生原的短类似物，6C和3C肽，产生了类似的效果。水螅肽形态发生原的含精氨酸类似物的给药显著减少了新生白化大鼠心室心肌中DNA合成核的数量。讨论了肽分子结构在水螅肽形态发生原形态发生效应实现中的作用。
