Priyadarshi A, Khuder S A, Schaub E A, Shrivastava S
Department of Public Health, Medical College of Ohio, Toledo, USA.
Neurotoxicology. 2000 Aug;21(4):435-40.
This study examined the association between Parkinson's disease (PD) and exposure to pesticides. A series of meta-analysis of peer-reviewed studies were performed, using 19 studies published between 1989 and 1999. Prior to the meta-analysis, all studies were reviewed and evaluated for heterogeneity and publication bias. Significant heterogeneity among studies was detected and combined odds ratio (OR) was calculated using the random effect model. The majority of the studies reported consistent elevation in the risk of PD with exposure to pesticides. The combined OR studies was 1.94 [95% confidence interval (95% CI) 1.49-2.53] for all the studies, and 2.15 (95% CI 1.14-4.05) for studies performed in United States. Although the risk of PD increased with increased duration of exposure to pesticides, no significant dose-response relation was established, and no specific type of pesticide was identified. Our findings suggest that exposure to pesticides may be a significant risk factor for developing PD.
本研究调查了帕金森病（PD）与接触杀虫剂之间的关联。利用1989年至1999年间发表的19项研究进行了一系列同行评审研究的荟萃分析。在进行荟萃分析之前，对所有研究进行了审查和评估，以确定其异质性和发表偏倚。检测到研究之间存在显著异质性，并使用随机效应模型计算合并优势比（OR）。大多数研究报告称，接触杀虫剂会使患帕金森病的风险持续升高。所有研究合并后的OR值为1.94[95%置信区间（95%CI）1.49 - 2.53]，在美国进行的研究中该值为2.15（95%CI 1.14 - 4.05）。尽管帕金森病的风险随着接触杀虫剂时间的延长而增加，但未建立显著的剂量反应关系，也未确定特定类型的杀虫剂。我们的研究结果表明，接触杀虫剂可能是患帕金森病的一个重要风险因素。
