Institute of Epidemiology, School of Medicine, University of Belgrade, Visegradska 26, Belgrade, 11000 Serbia.
Int J Neurosci. 2010 May;120(5):361-7. doi: 10.3109/00207451003668374.
A case-control study was performed in Belgrade in order to investigate the association between Parkinson's disease (PD) and some environmental factors. During the period 2001-2005, 110 new PD cases and 220 hospital controls were interviewed. Cases and controls were matched by sex, age (+/-2 years), and place of residence (urban/rural). According to multivariate conditional logistic regression analysis, PD was positively asssociated with exposure to insecticides (odds ratio (OR) 3.22, 95% confidence interval (95% CI) 1.32-7.87), dyes (OR 25.33; 95% CI, 2.89-222.0), and naphtha and its derivates (OR 9.53; 95% CI, 1.04-86.96), and with gardening (OR 5.51; 95% CI, 3.04-10.01), well water drinking (OR 2.62; 95% CI, 1.40-4.90), and spring water drinking (OR 2.19; 95% CI, 1.15-4.16). Negative association was found for service-sector working (OR 0.15; 95% CI, 0.04-0.59). The results obtained did not changed after adjustment for smoking. The findings of the present study support the role of environmental factors in the occurence of PD.
一项病例对照研究在贝尔格莱德进行，旨在调查帕金森病（PD）与一些环境因素之间的关联。在 2001-2005 年期间，对 110 例新的 PD 病例和 220 例医院对照进行了访谈。病例和对照按性别、年龄（+/-2 岁）和居住地（城市/农村）匹配。根据多变量条件逻辑回归分析，PD 与接触杀虫剂（比值比（OR）3.22，95%置信区间（95%CI）1.32-7.87）、染料（OR 25.33；95%CI，2.89-222.0）和石脑油及其衍生物（OR 9.53；95%CI，1.04-86.96）呈正相关，与园艺（OR 5.51；95%CI，3.04-10.01）、饮用井水（OR 2.62；95%CI，1.40-4.90）和饮用泉水（OR 2.19；95%CI，1.15-4.16）呈正相关，与服务业工作（OR 0.15；95%CI，0.04-0.59）呈负相关。在调整吸烟因素后，研究结果仍然不变。本研究的结果支持环境因素在 PD 发生中的作用。
