May J, Lell B, Luty A J, Meyer C G, Kremsner P G
Institut für Tropenmedizin Berlin und Medizinische Fakultät Charité, Humboldt-Universität zu Berlin, D-14050 Berlin, Germany.
J Infect Dis. 2000 Nov;182(5):1570-3. doi: 10.1086/315857. Epub 2000 Oct 9.
In individuals with severe malarial anemia, plasma levels of tumor necrosis factor (TNF)-alpha tend to exceed those of interleukin (IL)-10. In this study, IL-10:TNF plasma level ratios <1 were found to be a risk factor for both cerebral malaria and severe anemia (P=.009), whereas higher IL-10:TNF ratios were observed more frequently in hyperparasitemic individuals. When considering allelic variants of the TNF promoter in children with severe malaria, carriers of the wild type more frequently had an IL-10:TNF ratio >1 (P=.008). In contrast, individuals with a mutation at position -238 of the TNF promoter (TNF(-238A) and TNF(-376A/-238A)) consistently had lower IL-10 than TNF plasma levels (IL-10:TNF ratio <1; P=.003). Our results show that, in children with severe malaria, TNF promoter variants influence the balance of IL-10:TNF in the plasma, which, in turn, affects the outcome in terms of clinical complications.
在患有严重疟疾贫血的个体中，肿瘤坏死因子（TNF）-α的血浆水平往往超过白细胞介素（IL）-10的水平。在本研究中，发现IL-10:TNF血浆水平比值<1是脑型疟疾和严重贫血的危险因素（P = 0.009），而在高疟原虫血症个体中更频繁地观察到较高的IL-10:TNF比值。在患有严重疟疾的儿童中考虑TNF启动子的等位基因变体时，野生型携带者更频繁地具有IL-10:TNF比值>1（P = 0.008）。相比之下，TNF启动子-238位突变的个体（TNF(-238A)和TNF(-376A/-238A)）的IL-10血浆水平始终低于TNF（IL-10:TNF比值<1；P = 0.003）。我们的结果表明，在患有严重疟疾的儿童中，TNF启动子变体影响血浆中IL-10:TNF的平衡，进而影响临床并发症方面的结局。
