三元脂质混合物单分子层中的混溶临界压力。
Miscibility critical pressures in monolayers of ternary lipid mixtures.
作者信息
Keller S L, Anderson T G, McConnell H M
机构信息
Department of Chemistry, University of Washington, Seattle, Washington 98195, USA.
出版信息
Biophys J. 2000 Oct;79(4):2033-42. doi: 10.1016/S0006-3495(00)76451-4.
When phospholipids are mixed with cholesterol in a monolayer at an air-water interface, coexisting 2-dimensional liquid phases can be observed if the surface pressure, pi, is lower than the miscibility critical pressure, pi(c). Ternary mixtures of two phospholipid species with dihydrocholesterol have been reported to have critical pressures that are linearly proportional to the relative composition of the phospholipids. However, we report here that, if the acyl chains of the two phospholipids differ significantly in length or unsaturation, the behavior is markedly different. In this case, the critical pressure of the ternary mixture can be remarkably high, exceeding the critical pressures of the corresponding binary mixtures. High critical pressures are also seen in binary mixtures of phospholipid and dihydrocholesterol when the two acyl chains of the phospholipid differ sufficiently in length. Using regular solution theory, we interpret the elevated critical pressures of these mixtures as an attractive interaction between the phospholipid components.
当磷脂与胆固醇在气-水界面形成单分子层混合时，如果表面压力π低于混溶临界压力π(c)，则可以观察到共存的二维液相。据报道，两种磷脂与二氢胆固醇的三元混合物的临界压力与磷脂的相对组成呈线性比例关系。然而，我们在此报告，如果两种磷脂的酰基链在长度或不饱和度上有显著差异，其行为会明显不同。在这种情况下，三元混合物的临界压力可能会非常高，超过相应二元混合物的临界压力。当磷脂的两条酰基链长度差异足够大时，磷脂与二氢胆固醇的二元混合物中也会出现高临界压力。利用正规溶液理论，我们将这些混合物临界压力的升高解释为磷脂组分之间的吸引相互作用。
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