哺乳动物中含羧基末端RF酰胺的新型神经肽及其受体
New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals.
作者信息
Hinuma S, Shintani Y, Fukusumi S, Iijima N, Matsumoto Y, Hosoya M, Fujii R, Watanabe T, Kikuchi K, Terao Y, Yano T, Yamamoto T, Kawamata Y, Habata Y, Asada M, Kitada C, Kurokawa T, Onda H, Nishimura O, Tanaka M, Ibata Y, Fujino M
机构信息
Pharmaceutical Discovery Research Division, Takeda Chemical Industries Ltd., 10 Wadai, Tsukuba, Ibaraki 300-4293, Japan.
出版信息
Nat Cell Biol. 2000 Oct;2(10):703-8. doi: 10.1038/35036326.
Only a few RFamide peptides have been identified in mammals, although they have been abundantly found in invertebrates. Here we report the identification of a human gene that encodes at least three RFamide-related peptides, hRFRP-1-3. Cells transfected with a seven-transmembrane-domain receptor, OT7T022, specifically respond to synthetic hRFRP-1 and hRFRP-3 but not to hRFRP-2. RFRP and OT7T022 mRNAs are expressed in particular regions of the rat hypothalamus, and intracerebroventricular administration of hRFRP-1 increases prolactin secretion in rats. Our results indicate that a variety of RFamide-related peptides may exist and function in mammals.
尽管在无脊椎动物中已大量发现RFamide肽，但在哺乳动物中仅鉴定出少数几种。在此，我们报告鉴定出一个人类基因，该基因编码至少三种与RFamide相关的肽，即hRFRP-1至3。用七跨膜结构域受体OT7T022转染的细胞对合成的hRFRP-1和hRFRP-3有特异性反应，但对hRFRP-2无反应。RFRP和OT7T022 mRNA在大鼠下丘脑的特定区域表达，脑室内注射hRFRP-1可增加大鼠催乳素的分泌。我们的结果表明，多种与RFamide相关的肽可能在哺乳动物中存在并发挥作用。
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