McCombs C, Hom J, Talal N, Mishell R I
J Immunol. 1975 Dec;115(6):1695-9.
New Zealand Black (NZB) mice hyporespond after in vitro immunization to sheep erythrocytes but not after in vivo immunization. The difference between in vitro and in vivo immunization was found to involve a non-antigen-specific change in the spleen which occurs in vivo soon after priming. Adherent spleen cells from young NZB or control strain mice were compared in their ability to cooperate with nonadherent cells in the induction of a primary immune response to sheep erythrocytes in vitro. The results support the hypothesis that there is a functional deficiency of adherent cells in the spleens of unprimed NZB mice.
新西兰黑（NZB）小鼠在体外免疫绵羊红细胞后反应低下，但体内免疫后则不然。研究发现，体外免疫和体内免疫之间的差异涉及脾脏中一种非抗原特异性的变化，这种变化在初次免疫后不久就在体内发生。比较了年轻NZB小鼠或对照品系小鼠的黏附性脾细胞在体外与非黏附性细胞协同诱导对绵羊红细胞的初次免疫反应的能力。结果支持了未免疫的NZB小鼠脾脏中黏附性细胞存在功能缺陷这一假说。
