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Asymmetric Alkylation of Nitroalkanes We thank the National Science Foundation and the National Institutes of Health (NIH), General Medical Sciences, for their generous support of our programs. Rhône-Poulenc graciously provided a postdoctoral fellowship for J.-P. S. Mass spectra were provided by the Mass Spectrometry Facility of the University of California, San Francisco, supported by the NIH Division of Research Resources.

作者信息

Trost BM, Surivet JP

机构信息

Department of Chemistry Stanford University Stanford, CA 94305-5080 (USA).

出版信息

Angew Chem Int Ed Engl. 2000 Sep 1;39(17):3122-3124. doi: 10.1002/1521-3773(20000901)39:17<3122::aid-anie3122>3.0.co;2-8.

DOI:10.1002/1521-3773(20000901)39:17<3122::aid-anie3122>3.0.co;2-8
PMID:11028053
Abstract
摘要

相似文献

1
Asymmetric Alkylation of Nitroalkanes We thank the National Science Foundation and the National Institutes of Health (NIH), General Medical Sciences, for their generous support of our programs. Rhône-Poulenc graciously provided a postdoctoral fellowship for J.-P. S. Mass spectra were provided by the Mass Spectrometry Facility of the University of California, San Francisco, supported by the NIH Division of Research Resources.硝基烷烃的不对称烷基化 我们感谢美国国家科学基金会和美国国立卫生研究院（NIH）普通医学科学部对我们项目的慷慨支持。罗纳 - 普朗克公司慷慨地为J.-P.S.提供了博士后奖学金。质谱由加利福尼亚大学旧金山分校质谱分析设施提供，该设施由美国国立卫生研究院研究资源司资助。
Angew Chem Int Ed Engl. 2000 Sep 1;39(17):3122-3124. doi: 10.1002/1521-3773(20000901)39:17<3122::aid-anie3122>3.0.co;2-8.
2
An Atom-Economic Three-Carbon Chain Extension to Give Enamides We thank the National Science Foundation and the National Institutes of Health, General Medical Sciences, for their generous support of our programs and Rhône-Poulenc for partial financial support for J.P.S. Mass spectra were provided by the Mass Spectrometry Facility of the University of California, San Francisco, supported by the NIH Division of Research Resources.
Angew Chem Int Ed Engl. 2001 Apr 17;40(8):1468-1471.
3
An Asymmetric Synthesis of C-2-epi-Hygromycin A We thank the National Science Foundation and the National Institute of Health, General Medical Sciences, for their generous support of our programs. O.D. thanks the Association pour la Recherche contre le Cancer (ARC) for a postdoctoral fellowship. Mass spectra were kindly provided by the Mass Spectrometry Facility, University of San Francisco, supported by the NIH Division of Research Resources.C-2-表型潮霉素A的不对称合成 我们感谢美国国家科学基金会以及国立卫生研究院普通医学科学研究所对我们项目的慷慨支持。O.D.感谢抗癌研究协会（ARC）提供博士后奖学金。质谱由旧金山大学质谱分析中心友情提供，该中心由美国国立卫生研究院研究资源司资助。
Angew Chem Int Ed Engl. 2001 Oct 1;40(19):3658-3660. doi: 10.1002/1521-3773(20011001)40:19<3658::aid-anie3658>3.0.co;2-2.
4
Synthesis of the First (1-3:6,7-eta-Cyclodecadienyl)ruthenium Complex by the Intramolecular Reaction of an Alkene and a Vinylcyclopropane We thank the National Science Foundation and the National Institutes of Health (NIH), General Medical Sciences, for their generous support of our programs. We are grateful to A. Cole for solving the X-ray structure of 3. Mass spectra were provided by the Mass Spectrometry Facility of the University of California, San Francisco, supported by the NIH Division of Research Resources.通过烯烃与乙烯基环丙烷的分子内反应合成首例（1-3:6,7-η-环癸二烯基）钌配合物 我们感谢美国国家科学基金会以及美国国立卫生研究院（NIH）普通医学科学部对我们研究项目的慷慨支持。我们感谢A. 科尔解析了3的X射线晶体结构。质谱由加利福尼亚大学旧金山分校质谱分析设施提供，该设施得到了NIH研究资源司的支持。
Angew Chem Int Ed Engl. 2001 Mar 16;40(6):1114-1116. doi: 10.1002/1521-3773(20010316)40:6<1114::aid-anie11140>3.0.co;2-x.
5
The Spongistatins: Architecturally Complex Natural Products-Part Two: Synthesis of the C(29-51) Subunit, Fragment Assembly, and Final Elaboration to (+)-Spongistatin 2 Financial support was provided by the National Institutes of Health (National Cancer Institute) through Grant CA-70329, a NIH Postdoctoral Fellowship to C.S.B., a Japan Society for Promotion of Science Fellowship to N.M., and a Royal Society Fulbright Fellowship to V.A.D. We also thank the Daiichi Pharmaceutical Co., Ltd, and the Tanabe Seiyaku Co., Ltd for financial support. Finally we thank Dr George T. Furst, Dr. Patrick J. Carroll, and Dr. Rakesh Kohli of the University of Pennsylvania Spectroscopic Service Center for assistance in securing and interpreting high-field NMR spectra, X-ray crystal structures, and mass spectra, respectively.海绵他汀类化合物：结构复杂的天然产物——第二部分：C(29 - 51)亚基的合成、片段组装以及(+)-海绵他汀2的最终合成 本研究得到了美国国立卫生研究院（国立癌症研究所）的资助，资助编号为CA - 70329；还给C.S.B.提供了美国国立卫生研究院博士后奖学金，给N.M.提供了日本学术振兴会奖学金，给V.A.D.提供了英国皇家学会富布赖特奖学金。我们还感谢第一制药株式会社和田边制药株式会社提供的资金支持。最后，我们感谢宾夕法尼亚大学光谱服务中心的George T. Furst博士、Patrick J. Carroll博士和Rakesh Kohli博士，他们分别在获取和解释高场核磁共振谱、X射线晶体结构以及质谱方面提供了帮助。
Angew Chem Int Ed Engl. 2001 Jan 5;40(1):196-199.
6
(-)-Rhizochalin is a Dimeric Enantiomorphic (2R)-Sphingolipid: Absolute Configuration of Pseudo-C(2v)-Symmetric Bis-2-amino-3-alkanols by CD We thank Jeff de Ropp and John MacMillan (University of California, Davis) for assistance with the 600 and 400 MHz (1)H NMR spectra, respectively; Gillian Nicholas (University of California, Davis) for measurement of the CD spectra of 7 a, b; Rich Kondrat (University of California, Riverside Mass Spectrometry Facility) for chemical ionization MS; and Carlito Lebrilla and Yongming Xie (University of California, Davis) for matrix-assisted laser desorption/ionization MS. This work was supported by the National Institutes of Health (NIH; grant no. AI 39987). The NMR spectrometers were funded in part by the National Science Foundation (grant no. CHE-9808183; 400 MHz apparatus) and the NIH (grant no. RR11973; 600 MHz apparatus). CD=circular dichroism.（-）-根赤壳菌素是一种二聚体对映体形式的（2R）-鞘脂：通过圆二色性确定伪C（2v）对称双-2-氨基-3-链烷醇的绝对构型 我们感谢Jeff de Ropp和John MacMillan（加利福尼亚大学戴维斯分校）分别在600和400 MHz 1H NMR光谱方面提供的帮助；感谢Gillian Nicholas（加利福尼亚大学戴维斯分校）测量7 a、b的圆二色光谱；感谢Rich Kondrat（加利福尼亚大学河滨分校质谱分析设施）进行化学电离质谱分析；感谢Carlito Lebrilla和Yongming Xie（加利福尼亚大学戴维斯分校）进行基质辅助激光解吸/电离质谱分析。本研究得到了美国国立卫生研究院（NIH；资助号AI 39987）的支持。核磁共振光谱仪部分由美国国家科学基金会（资助号CHE-9808183；400 MHz仪器）和美国国立卫生研究院（资助号RR11973；600 MHz仪器）资助。CD=圆二色性
Angew Chem Int Ed Engl. 2000 Nov 17;39(22):4076-4079.
7
Model Studies towards Diazonamide A: Synthesis of the Heterocyclic Core We thank Dr. D. H. Huang, Dr. G. Suizdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. We also thank Professor R. H. Grubbs for a generous gift of catalyst 30. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (S.A.S.), postdoctoral fellowships from the Alfred Benzons Foundation and the Danish Natural Science Research Council (K.B.S.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, GlaxoWellcome, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.
Angew Chem Int Ed Engl. 2000 Oct 2;39(19):3473-3478. doi: 10.1002/1521-3773(20001002)39:19<3473::aid-anie3473>3.0.co;2-e.
8
The Spongistatins: Architecturally Complex Natural Products-Part One: A Formal Synthesis of (+)-Spongistatin 1 by Construction of an Advanced ABCD Fragment Financial support was provided by the National Institutes of Health (National Cancer Institute) through Grant CA-70329, NIH Postdoctoral Fellowships to A.M.B. and W.H.M., a Japan Society for Promotion of Science Fellowship to N.M., and a Royal Society Fulbright Fellowship to V.A.D. We also thank the Daiichi Pharmaceutical Co., Ltd, and the Tanabe Seiyaku Co., Ltd for financial support. Finally we thank Dr. George T. Furst, Dr. Patrick J. Carroll, Dr. Rakesh Kohli, and Mr John Dykins of the University of Pennsylvania Spectroscopic Service Center for assistance in securing and interpreting high-field NMR spectra, X-ray crystal structures, and mass spectra.海绵他汀类化合物：结构复杂的天然产物——第一部分：通过构建高级ABCD片段对（+）-海绵他汀1进行形式合成 美国国立卫生研究院（国家癌症研究所）通过CA-70329号资助提供了资金支持，美国国立卫生研究院向A.M.B.和W.H.M.提供了博士后奖学金，日本学术振兴会向N.M.提供了奖学金，英国皇家学会富布赖特奖学金向V.A.D.提供了奖学金。我们还感谢第一制药株式会社和田边制药株式会社的资金支持。最后，我们感谢宾夕法尼亚大学光谱服务中心的George T. Furst博士、Patrick J. Carroll博士、Rakesh Kohli博士和John Dykins先生在获取和解释高场核磁共振光谱、X射线晶体结构和质谱方面提供的帮助。
Angew Chem Int Ed Engl. 2001 Jan 5;40(1):191-195.
9
Asymmetric Synthesis of Phorboxazole B-Part I: Synthesis of the C(20)-C(38) and C(39)-C(46) Subunits Financial support was provided by the National Institutes of Health (GM-33328) and the National Science Foundation. An American Cancer Society Postdoctoral Fellowship to T.E.S. and an NSF Predoctoral Fellowship to V.J.C. are gratefully acknowledged. The NIH BRS Shared Instrumentation Grant Program 1-S10-RR04870 and the NSF (CHE 88-14019) are acknowledged for providing NMR facilities.佛波酯B的不对称合成——第一部分：C(20)-C(38)和C(39)-C(46)亚基的合成 美国国立卫生研究院（GM-33328）和美国国家科学基金会提供了资金支持。衷心感谢美国癌症协会授予T.E.S.的博士后奖学金以及美国国家科学基金会授予V.J.C.的博士前奖学金。感谢美国国立卫生研究院BRS共享仪器资助计划1-S10-RR04870和美国国家科学基金会（CHE 88-14019）提供核磁共振设施。
Angew Chem Int Ed Engl. 2000 Jul 17;39(14):2533-2536. doi: 10.1002/1521-3773(20000717)39:14<2533::aid-anie2533>3.0.co;2-b.
10
Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1 Financial support was provided by the EPSRC (GR/L41646), Cambridge Commonwealth Trust (Scholarship to M.J.C.), EC (Marie Curie Postdoctoral Fellowship to J.L.A.), DFG (Postdoctoral Fellowship to T.T.), NSERC-Canada (Postdoctoral Fellowship to R.M.O.), Churchill College (Research Fellowship to D.J.W.), Kingapos;s College and Sims Fund, Cambridge (Scholarship to D.Y.K.C.). We also thank Merck and AstraZeneca Pharmaceuticals for generous support, and Dr. Anne Butlin (AZ) and Dr. Nick Bampos (Cambridge) for valuable assistance.（+）-Altohyrtin A/海绵抑素1的立体控制全合成 本研究得到了英国工程与自然科学研究委员会（GR/L41646）、剑桥联邦信托基金（授予M.J.C.的奖学金）、欧盟（授予J.L.A.的玛丽·居里博士后奖学金）、德国研究基金会（授予T.T.的博士后奖学金）、加拿大自然科学与工程研究理事会（授予R.M.O.的博士后奖学金）、丘吉尔学院（授予D.J.W.的研究奖学金）、国王学院和剑桥西姆斯基金（授予D.Y.K.C.的奖学金）的资金支持。我们还要感谢默克公司和阿斯利康制药公司的慷慨支持，以及安妮·巴特林博士（阿斯利康）和尼克·班波斯博士（剑桥）提供的宝贵帮助。
Angew Chem Int Ed Engl. 2001 Nov 5;40(21):4055-4060.

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