Graham B S, Barr R J
Department of Dermatology, University of California, Irvine, USA.
J Cutan Pathol. 2000 Oct;27(9):455-9. doi: 10.1034/j.1600-0560.2000.027009455.x.
There is a large spectrum trichoblastoma; of which, several histologic variants have been described including a rippled-pattern variant. Three cases of rippled-pattern trichoblastoma are described which also exhibited definitive foci of sebaceous differentiation.
Three cases were retrieved from the archives of the Dermatopathology Laboratory at the University of California Irvine (Orange, CA, USA). All specimens were stained with hematoxylin and eosin (H&E). In addition, sections were submitted for immunohistochemical studies with epithelial membrane antigen (EMA).
All three biopsies were composed of well-circumscribed multiple variously sized tumor lobules present in the upper to deep dermis comprised of with rounded or slightly elongated basaloid cells with scant eosinophilic cytoplasm. The lobules were separated by a slightly hyalinized stroma. The unique finding present in all three specimens was a peculiar arrangement of the basaloid cells in linear rows parallel to one another. This gave the tumors a rippled pattern similar to the palisading of nuclei of Verocay bodies seen in schwannomas. In addition all three biopsies showed definite sebaceous differentiation.
Three additional cases of rippled-pattern trichoblastoma are presented. All three were located on the scalp and showed additional features of foci of sebaceous differentiation. No associations with Muir-Torre Syndrome were found in these patients. Because this appears to be a distinct variant within the large spectrum of trichoblastoma, the term rippled-pattern sebaceous trichoblastoma is suggested.
毛发母细胞瘤存在多种类型；其中，已描述了几种组织学变体，包括波纹状模式变体。本文描述了3例波纹状模式毛发母细胞瘤，这些病例还表现出明确的皮脂腺分化灶。
从美国加利福尼亚大学欧文分校（美国加利福尼亚州奥兰治）皮肤病理学实验室的档案中检索出3例病例。所有标本均用苏木精和伊红（H&E）染色。此外，切片还进行了上皮膜抗原（EMA）的免疫组织化学研究。
所有3例活检标本均由界限清楚的多个大小不一的肿瘤小叶组成，位于真皮浅层至深层，由圆形或略呈拉长状的基底样细胞构成，胞质嗜酸性淡染。小叶被轻度玻璃样变的间质分隔。所有3个标本中独特的发现是基底样细胞彼此平行排列成线性行。这使肿瘤呈现出一种波纹状模式，类似于在神经鞘瘤中所见的Verocay小体细胞核的栅栏状排列。此外，所有3例活检均显示明确的皮脂腺分化。
本文报告了另外3例波纹状模式毛发母细胞瘤。所有3例均位于头皮，且表现出皮脂腺分化灶的其他特征。这些患者未发现与穆尔-托里综合征相关。由于这似乎是毛发母细胞瘤众多类型中的一种独特变体，建议使用“波纹状模式皮脂腺毛发母细胞瘤”这一术语。
