Kiyohara Takahiro, Kumakiri Masanobu, Kuwahara Hiroaki, Saitoh Atsuko, Ansai Shinichi
Department of Dermatology, University of Fukui, Fukui, Japan.
Am J Dermatopathol. 2006 Oct;28(5):446-8. doi: 10.1097/01.dad.0000211504.14371.b2.
A 68-year-old Japanese man presented with a nodule that had been present for 5 to 6 years on the right side of the back. Physical examination revealed a dome-shaped, 12 x 13-mm, dark red nodule. It was excised with a 2 to 3-mm margin. The patient remained free of disease during 77 months of follow-up. Microscopic examination revealed a bulb-like tumor in the dermis, contiguous with the overlying epidermis. It was composed of small, monomorphous, cigar-shaped basaloid cells in linear, parallel rows, resembling the palisading of nuclei of Verocay bodies, and presenting a rippled-pattern. There were scattered cells showing sebaceous differentiation with vacuolated cytoplasm and scalloped nuclei. There were tiny, duct-like spaces. The tumor revealed characteristics of rippled-pattern sebaceoma. The present case is the first reported rippled-pattern sebaceous neoplasm on the back. Many spindle cell tumors, such as basal cell carcinoma, pleomorphic adenoma, dermatofibrosarcoma protuberans, myofibroblastoma, and leiomyoblastoma, in addition to trichoblastoma and sebaceoma, can have a rippled-pattern.
一名68岁的日本男性因背部右侧出现一个已存在5至6年的结节前来就诊。体格检查发现一个圆顶状、12×13毫米的暗红色结节。以2至3毫米的切缘将其切除。在77个月的随访期间,患者未出现疾病复发。显微镜检查显示真皮内有一个灯泡样肿瘤,与上方表皮相连。它由小的、形态单一的、雪茄状的基底样细胞呈线性、平行排列组成,类似于Verocay小体细胞核的栅栏状排列,并呈现出波纹状模式。有散在的细胞显示皮脂腺分化,细胞质有空泡,细胞核呈扇贝状。有微小的导管样间隙。该肿瘤显示出波纹状皮脂腺瘤的特征。本病例是首次报道的背部波纹状皮脂腺肿瘤。除了毛母细胞瘤和皮脂腺瘤外,许多梭形细胞肿瘤,如基底细胞癌、多形性腺瘤、隆突性皮肤纤维肉瘤、肌成纤维细胞瘤和平滑肌瘤母细胞瘤,都可以有波纹状模式。