Gerdsen R, Stockfleth E, Uerlich M, Fartasch M, Steen K H, Bieber T
Department of Dermatology, University of Bonn, Germany.
Acta Derm Venereol. 2000 Jul-Aug;80(4):292-3. doi: 10.1080/000155500750012207.
This study presents the case of a 38-year-old patient from Pakistan with vitiligo, who developed multiple verrucous papules on the palms and soles several years after receiving "herbal treatment" from a travelling Indian doctor for a period of 12 months. Histopathological examination showed changes consistent with the diagnosis of arsenical keratosis. Molecularbiological examination of a skin biopsy detected an atypical human papillomavirus. This observation supports the concept of human papillomavirus as a co-factor in the pathogenesis of premalignant arsenic-induced skin tumours.
本研究报告了一名来自巴基斯坦的38岁白癜风患者的病例，该患者在接受一名游走的印度医生为期12个月的“草药治疗”数年之后，手掌和脚底出现了多个疣状丘疹。组织病理学检查显示的变化符合砷角化病的诊断。对皮肤活检进行的分子生物学检查检测到一种非典型人乳头瘤病毒。这一观察结果支持了人乳头瘤病毒作为癌前砷诱导性皮肤肿瘤发病机制中的一个辅助因素的概念。
