Dumond YR, Baker RL, Montchamp JL
Department of Chemistry, Box 298860, Texas Christian University, Fort Worth, Texas 76129, USA.
Org Lett. 2000 Oct 19;2(21):3341-4. doi: 10.1021/ol006434g.
Monosubstituted phosphinic acids are esterified with orthosilicates in excellent yields. Phosphinylidene-containing acids react selectively under these conditions, while disubstituted phosphinic acids and phosphonic acids remain unchanged. One-pot procedures are also described for the preparation of phosphinate esters from an alcohol. This novel method provides a convenient and general alternative to more commonly employed conditions such as diazomethane or carbodiimide.
单取代次膦酸与原硅酸盐酯化反应的产率极高。含亚膦基的酸在这些条件下会选择性地发生反应，而二取代次膦酸和膦酸则保持不变。文中还描述了由醇制备次膦酸酯的一锅法。这种新方法为诸如重氮甲烷或碳二亚胺等更常用的条件提供了一种方便且通用的替代方法。
