Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA.
Fertil Steril. 2010 Apr;93(6):1929-37. doi: 10.1016/j.fertnstert.2008.12.056. Epub 2009 Feb 24.
To study the effects of combination hormone therapy (HT) on emotional processing in postmenopausal women with use of functional neuroimaging.
A randomized, double-blind, placebo-controlled crossover study was performed.
A tertiary care university medical center.
PARTICIPANT(S): Ten healthy postmenopausal women (mean age 56.9 years, SD = 1.4 years) were recruited.
INTERVENTION(S): Women were assigned randomly to the order they received combined HT, 5 microg ethinyl E(2) and 1 mg norethindrone acetate, and placebo. Volunteers received HT or placebo for 4 weeks, followed by a 1-month washout period, and then received the other treatment for 4 weeks. Subjects participated in a functional magnetic resonance imaging emotional processing task, where they were asked to rate emotional pictures as positive, negative, or neutral.
MAIN OUTCOME MEASURE(S): Brain activation patterns were compared between HT and placebo conditions within subjects.
RESULT(S): During negative emotional presentations, after subtracting the effect of neutral images, areas of significant differences between HT and placebo conditions were identified in the orbital, frontal, cingulate, and occipital cortices. During positive emotional image presentation there were significant differences between placebo and HT conditions within the medial frontal cortex.
Short-term menopausal treatment with combination HT affects regional brain activity within areas implicated in emotional processing.
使用功能神经影像学研究联合激素治疗（HT）对绝经后妇女情绪处理的影响。
这是一项随机、双盲、安慰剂对照的交叉研究。
一家三级护理大学医疗中心。
招募了 10 名健康的绝经后妇女（平均年龄 56.9 岁，SD=1.4 岁）。
妇女随机分配接受联合 HT（5 微克乙炔雌二醇和 1 毫克去氧孕烯醋酸酯）或安慰剂治疗。志愿者接受 HT 或安慰剂治疗 4 周，然后进行 1 个月的洗脱期，然后再接受另一种治疗 4 周。受试者参加了一项功能磁共振成像情绪处理任务，要求他们对情绪图片进行积极、消极或中性的评分。
在受试者内部比较 HT 和安慰剂条件下的大脑激活模式。
在呈现负面情绪时，在减去中性图像的影响后，HT 和安慰剂条件之间存在显著差异的区域位于眶额、额、扣带回和枕叶皮质。在呈现积极情绪图像时，内侧额皮质内安慰剂和 HT 条件之间存在显著差异。
短期绝经治疗联合 HT 会影响情绪处理相关区域的大脑区域活动。
