中国人乳腺癌中的人乳头瘤病毒33型DNA
Human papillomavirus type 33 DNA in breast cancer in Chinese.
作者信息
Yu Y, Morimoto T, Sasa M, Okazaki K, Harada Y, Fujiwara T, Irie Y, Takahashi E, Tanigami A, Izumi K
机构信息
Department of Pathology, Shanghai First People's Hospital, China.
出版信息
Breast Cancer. 2000 Jan;7(1):33-6. doi: 10.1007/BF02967185.
BACKGROUND
The association between human papillomavirus (HPV) and anogenital tumors, especially cervical cancer, is well documented. However, it remains unclear whether there is also a correlation between HPV infection and human breast cancer.
METHODS
We used PCR and Southern blot hybridization to analyze HPV-related DNA specimens from 32 cases of invasive ductal carcinoma operated upon in the Shanghai region of China.
RESULTS
DNA derived from HPV33 was detected in 14 cases (43.8%). No HPV16 or HPV18 DNA was detected in any of the cases in this study. This is the first report demonstrating a correlation between HPV33 infection and breast cancer.
CONCLUSIONS
Our results suggest that HPV33 infection may be involved in the pathogenesis of breast cancer in Chinese.
背景
人乳头瘤病毒（HPV）与肛门生殖器肿瘤，尤其是宫颈癌之间的关联已有充分记录。然而，HPV感染与人类乳腺癌之间是否也存在相关性仍不清楚。
方法
我们使用聚合酶链反应（PCR）和Southern印迹杂交技术，对来自中国上海地区32例浸润性导管癌手术切除标本中的HPV相关DNA进行分析。
结果
在14例（43.8%）病例中检测到源自HPV33的DNA。本研究中所有病例均未检测到HPV16或HPV18 DNA。这是首份证明HPV33感染与乳腺癌之间存在相关性的报告。
结论
我们的结果表明，HPV33感染可能参与中国人乳腺癌的发病机制。
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