Gupta Ishita, Jabeen Ayesha, Al-Sarraf Reem, Farghaly Hanan, Vranic Semir, Sultan Ali A, Al Moustafa Ala-Eddin, Al-Thawadi Hamda
College of Medicine, QU Health, Qatar University, Doha, Qatar.
Biomedical Research Centre, QU Health, Qatar University, Doha, Qatar.
Hum Vaccin Immunother. 2021 Apr 3;17(4):982-989. doi: 10.1080/21645515.2020.1802977. Epub 2020 Oct 2.
High-risk human papillomaviruses (HPV) can be present and cooperate with Epstein-Barr virus (EBV) to promote the onset and/or progression of various cancers including cervical, breast, head and neck as well as colorectal. In this investigation, we explored the co-prevalence of high-risk HPV and EBV in 74 breast cancer tissues from Qatari women using polymerase chain reaction. We found that high-risk HPV and EBV are present in 48/74 (65%) and 36/74 (49%) of the cases, respectively. While we noted that the presence of HPV presence is associated with triple-negative breast cancer (TNBC) ( = .008), however, the presence of EBV did not correlate with any breast cancer subgroup. Moreover, our data revealed that high-risk HPV and EBV are co-present in 35/74 (47%) of the samples and their co-presence is significantly associated with tumor grade ( = .04) and tumor stage ( = .04). These data indicate that HPV and EBV are commonly co-present in breast cancer and their association could be linked with a more aggressive tumor phenotype. Thus, further investigations are essential to understand the underlying mechanisms of HPV and EBV cooperation in breast carcinogenesis.
高危型人乳头瘤病毒（HPV）可能存在，并与爱泼斯坦-巴尔病毒（EBV）协同作用，促进包括宫颈癌、乳腺癌、头颈癌以及结直肠癌在内的多种癌症的发生和/或进展。在本研究中，我们使用聚合酶链反应，对74例卡塔尔女性乳腺癌组织中高危型HPV和EBV的共同流行情况进行了探究。我们发现，高危型HPV和EBV分别存在于48/74（65%）和36/74（49%）的病例中。虽然我们注意到HPV的存在与三阴性乳腺癌（TNBC）相关（P = 0.008），然而，EBV的存在与任何乳腺癌亚组均无关联。此外，我们的数据显示，35/74（47%）的样本中同时存在高危型HPV和EBV，它们的共同存在与肿瘤分级（P = 0.04）和肿瘤分期（P = 0.04）显著相关。这些数据表明，HPV和EBV在乳腺癌中通常共同存在，它们之间的关联可能与更具侵袭性的肿瘤表型有关。因此，进一步的研究对于了解HPV和EBV在乳腺癌发生过程中协同作用的潜在机制至关重要。
