Uemura A, Thomas M A
Barnes Retina Institute, One Barnes Hospital Plaza, Suite 17413 East Pavilion, St Louis, MO 63110, USA.
Arch Ophthalmol. 2000 Oct;118(10):1373-8. doi: 10.1001/archopht.118.10.1373.
To assess the visual outcome after surgical removal of choroidal neovascularization (CNV) in pediatric patients.
A retrospective, noncomparative, consecutive case series of 17 eyes undergoing surgical removal of CNV of various causes in patients aged 18 years and younger.
The cause of the CNV was presumed ocular histoplasmosis syndrome in 11 eyes, idiopathic in 3, and optic nerve coloboma, ocular toxoplasmosis, and trauma in 1 eye each. Two eyes had CNV within 100 microm of the center of the foveal avascular zone (juxtafoveal CNV) and 1 eye had peripapillary CNV, while 14 eyes had CNV beneath the geometric center of the foveal avascular zone (subfoveal CNV). In eyes with subfoveal CNV, median preoperative Snellen visual acuity was 20/200 (range, 20/80-3/200). With a median follow-up of 27 months (range, 6-45 months), median final visual acuity was 20/50 (range, 20/20-2/200); 10 (72%) had improvement of 2 or more Snellen lines after surgery, and 6 eyes (43%) had final visual acuity of 20/40 or better. In 3 eyes with juxtafoveal CNV or peripapillary CNV, all eyes had improvement of 4 or more Snellen lines. Postoperative recurrent CNV developed in 6 (35%) of 17 patients; 2 of the eyes underwent a second vitrectomy and 4 received laser treatment for the recurrences.
Pediatric patients may have good recovery of vision after surgical removal of CNV, and the removal of these membranes may be a viable alternative to laser photocoagulation in pediatric patients.
评估小儿患者脉络膜新生血管(CNV)手术切除后的视力预后。
对18岁及以下因各种原因接受CNV手术切除的17只眼进行回顾性、非对照、连续病例系列研究。
11只眼的CNV病因推测为眼组织胞浆菌病综合征,3只为特发性,视神经缺损、眼弓形虫病和外伤各1只眼。2只眼的CNV位于黄斑无血管区中心100微米内(黄斑旁CNV),1只眼有视乳头周围CNV,14只眼的CNV位于黄斑无血管区几何中心下方(黄斑下CNV)。黄斑下CNV的眼中,术前Snellen视力中位数为20/200(范围20/80 - 3/200)。中位随访27个月(范围6 - 45个月),最终视力中位数为20/50(范围20/20 - 2/200);10只眼(72%)术后Snellen视力提高2行或更多,6只眼(43%)最终视力达到20/40或更好。3只黄斑旁CNV或视乳头周围CNV的眼中,所有眼的Snellen视力均提高4行或更多。17例患者中有6例(35%)术后出现CNV复发;其中2只眼接受了二次玻璃体切除术,4只眼因复发接受了激光治疗。
小儿患者手术切除CNV后视力可能恢复良好,对于小儿患者,切除这些膜可能是激光光凝的一种可行替代方法。