Nishide T, Kadonosono K, Itoh N, Yazama F, Endoh Y, Sawada H, Ohno S
Department of Ophthalmology, Yokohama City University School of Medicine, Yokahama, Japan
Jpn J Ophthalmol. 2000 Sep 1;44(5):569. doi: 10.1016/s0021-5155(00)00237-9.
Purpose: Recently, intraocular lidocaine anesthesia has been used in cataract surgery. We studied the toxicity of intraocular unpreserved lidocaine for corneal endothelial cell and retina using Japanese white rabbits.Methods: The rabbits were divided into two groups. One group was injected intracamerally and the other was injected intravitreally with 0.2 ml of unpreserved lidocaine of 0%, 0.02%, 0.2%, or 2% concentration. The number of corneal endothelial cells was measured 1 week after the injection. After measurements, the rabbit corneas were studied histologically. The retina was examined by electroretinogram prior to initial injection through 1 week after the injection.Results: There was no significant change in number of corneal endothelial cells after injection of 0.2% lidocaine. However, histological abnormality was seen in corneal endothelial cells after 2% lidocaine injection. There was also significant change in electroretinogram with 2% lidocaine injection. No histological abnormality was seen in the retina 1 week after the injection.Conclusion: The rabbit cornea and retina manifested no serious changes after the injection of lidocaine at less than 0.2% concentration functionally and histologically.
最近，眼内利多卡因麻醉已用于白内障手术。我们使用日本白兔研究了眼内未保存的利多卡因对角膜内皮细胞和视网膜的毒性。
将兔子分为两组。一组通过前房内注射，另一组通过玻璃体内注射0.2毫升浓度为0%、0.02%、0.2%或2%的未保存利多卡因。注射后1周测量角膜内皮细胞数量。测量后，对兔角膜进行组织学研究。在初次注射前至注射后1周通过视网膜电图检查视网膜。
注射0.2%利多卡因后角膜内皮细胞数量无显著变化。然而，注射2%利多卡因后角膜内皮细胞出现组织学异常。注射2%利多卡因后视网膜电图也有显著变化。注射后1周视网膜未见组织学异常。
浓度低于0.2%的利多卡因注射后，兔角膜和视网膜在功能和组织学上均未表现出严重变化。
