Nishi O, Nishi K, Wickström K
Nishi Eye Hospital, Osaka, Japan.
J Cataract Refract Surg. 2000 Oct;26(10):1543-9. doi: 10.1016/s0886-3350(00)00426-0.
To compare the preventive effect on posterior capsule opacification (PCO) of an acrylic intraocular lens (IOL) and a silicone IOL, both with sharp rectangular optic edges.
Jinshikai Medical Foundation, Nishi Eye Hospital, Osaka, Japan.
After phacoemulsification, an acrylic IOL (AcrySof(R)) was implanted in 1 eye and a silicone IOL (CeeOn 911) in the contralateral eye of 7 rabbits, one of which was omitted from evaluation.
The Miyake-Apple view and histopathological findings 3 weeks after surgery revealed that the lens capsule wrapped tightly around the optic edges, conforming to a distinctly sharp bend, with both IOL types in 5 rabbits. Migrating lens epithelial cells (LECs) were inhibited at the site. The AcrySof IOL had a better capsular bend effect in the histological sections, but there was no apparent difference in PCO development between the 2 IOLs.
The CeeOn 911 silicone IOL, with sharp rectangular optic edges, showed an effect on preventing PCO that was similar to that of the AcrySof IOL. When a discontinuous capsular bend is created by an IOL with sharp optic edges, the bend may induce contact inhibition of migrating LECs regardless of the lens' material composition.
比较具有锐利矩形光学边缘的丙烯酸人工晶状体（IOL）和硅酮IOL对后囊膜混浊（PCO）的预防效果。
日本大阪西眼科医院金石凯医学基金会。
在7只兔子中，一只兔子被排除在评估之外，其余兔子在白内障超声乳化术后，一只眼睛植入丙烯酸IOL（AcrySof®），对侧眼睛植入硅酮IOL（CeeOn 911）。
术后3周的三宅-苹果视图和组织病理学结果显示，在5只兔子中，两种IOL类型的晶状体囊膜都紧紧包裹在光学边缘周围，形成明显尖锐的弯曲。迁移的晶状体上皮细胞（LECs）在该部位受到抑制。在组织学切片中，AcrySof IOL具有更好的囊膜弯曲效果，但两种IOL在PCO发展方面没有明显差异。
具有锐利矩形光学边缘的CeeOn 911硅酮IOL显示出与AcrySof IOL相似的预防PCO的效果。当具有锐利光学边缘的IOL产生不连续的囊膜弯曲时，无论晶状体的材料成分如何，这种弯曲可能会诱导迁移的LECs的接触抑制。
