Papamandjaris A A, White M D, Raeini-Sarjaz M, Jones P J
School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Ste-Anne-de-Bellevue, Quebec, Canada.
Int J Obes Relat Metab Disord. 2000 Sep;24(9):1158-66. doi: 10.1038/sj.ijo.0801350.
To compare the effect of medium chain triglycerides (MCT) vs long chain triglycerides (LCT) feeding on exogenous and endogenous oxidation of long chain saturated fatty acids (LCSFA) in women.
Twelve healthy female subjects (age 19-26 y, body mass index (BMI) 17.5-28.6 kg/m2)
In a randomized cross-over design, subjects were fed weight maintenance diets providing 15%, 45% and 40% of energy as protein, carbohydrate and fat, respectively, with 80% of this fat comprising either a combination of butter and coconut oil (MCT) or beef tallow (LCT). Following 6 days of feeding, subjects were given daily oral doses of 1-(13)C labelled-myristic, -palmitic and -stearic acids for 8 days. Expired 13CO2 was used as an index of LCSFA oxidation with CO2 production assessed by respiratory gas exchange.
No difference in exogenous LCSFA oxidation was observed as a function of diet on day 7. On day 14, greater combined cumulative fractional LCSFA oxidation (16.9 +/- 2.5%/5.5 h vs 9.1 +/- 1.2%/5.5 h, P < 0.007), net LCSFA oxidation (2956 +/- 413 mg/5.5 h vs 1669 +/- 224 mg/5.5 h, P < 0.01), and percentage dietary LCSFA contribution to total fat oxidation (16.3 +/- 2.3%/5.5 h vs 9.5 +/- 1.5%/5.5 h; P < 0.01) were observed in women fed the MCT vs LCT diet. With the MCT diet, but not the LCT diet, combined cumulative fractional LCSFA oxidation (P < 0.03), net LCSFA oxidation (P < 0.03), and percentage dietary LCSFA contribution to total fat oxidation (P < 0.02) were increased at day 14 as compared to day 7. Day 14 results indicated increased endogenous LCSFA oxidation during MCT feeding.
The capacity of MCT to increase endogenous oxidation of LCSFA suggests a role for MCT in body weight control over the long term.
比较中链甘油三酯（MCT）与长链甘油三酯（LCT）喂养对女性长链饱和脂肪酸（LCSFA）外源性和内源性氧化的影响。
12名健康女性受试者（年龄19 - 26岁，体重指数（BMI）17.5 - 28.6kg/m²）
采用随机交叉设计，受试者食用维持体重的饮食，其中蛋白质、碳水化合物和脂肪分别提供15%、45%和40%的能量，该脂肪的80%由黄油和椰子油的组合（MCT）或牛脂（LCT）组成。喂养6天后，受试者连续8天每日口服剂量为1 - （13）C标记的肉豆蔻酸、棕榈酸和硬脂酸。呼出的13CO₂用作LCSFA氧化的指标，通过呼吸气体交换评估CO₂产生量。
在第7天，未观察到外源性LCSFA氧化因饮食不同而有差异。在第14天，与食用LCT饮食的女性相比，食用MCT饮食的女性中，长链饱和脂肪酸（LCSFA）的联合累积分数氧化（16.9±2.5%/5.5小时对9.1±1.2%/5.5小时，P<0.007）、净LCSFA氧化（2956±413mg/5.5小时对1669±224mg/5.5小时，P<0.01）以及膳食LCSFA对总脂肪氧化的贡献百分比（16.3±2.3%/5.5小时对9.5±1.5%/5.5小时；P<0.01）均更高。对于MCT饮食组，与第7天相比，第14天时LCSFA联合累积分数氧化（P<0.03）、净LCSFA氧化（P<0.03）以及膳食LCSFA对总脂肪氧化的贡献百分比（P<0.02）均增加，但LCT饮食组未出现此情况。第14天的结果表明，MCT喂养期间内源性LCSFA氧化增加。
MCT增加LCSFA内源性氧化的能力表明其在长期体重控制中发挥作用。
