Tubercle. 1975 Jun;56(2):81-96. doi: 10.1016/0041-3879(75)90020-3.
A comparison has been made between 6- and 9-month regimens of streptomycin, isoniazid and pyrazinamide given daily, 3 times a week or twice a week from the start of chemotherapy, in the treatment of newly-diagnosed, smear-positive, pulmonary tuberculosis in Chinese patients. At 6 months the twice-weekly regimen was marginally inferior in that 5 (4 per cent) of 126 patients with drug-sensitive strains pretreatment had an unfavourable bacteriological status compared with only 2 (1 per cent) of 141 on the 3 times weekly and none of 137 of the daily regimen. Of a total of 211 patients treated for 9 months, only 1 of 74 on the twice-weekly regimen relapsed bacteriologically between 6 and 9 months. The bacteriological relapse rates in the first 6 months of follow-up after 6 months' chemotherapy were 13 per cent on the daily, 16 per cent on the 3 times weekly, and 18 per cent on the twice-weekly regimen, and after 9 months' chemotherapy they were 3 per cent, 4 per cent and 4 per cent respectively. All 33 relapses were with strains sensitive to isoniazid and streptomycin, and 76 per cent of them occurred in the first 3 months after the end of chemotherapy. Although patients with drug-resistant strains pretreatment fared less well, about two-thirds had a favourable bacteriological status at 6 months, and all 3 regimens given for 9 months had low relapse rates. The implications of these findings are discussed.
对中国新诊断的涂片阳性肺结核患者，从化疗开始就每日、每周3次或每周2次给予链霉素、异烟肼和吡嗪酰胺6个月和9个月疗程进行了比较。在6个月时，每周2次的疗程略逊一筹，因为126例预处理为药物敏感菌株的患者中有5例（4%）细菌学状态不佳，而每周3次给药的141例中只有2例（1%），每日给药方案的137例中无一例出现这种情况。在总共211例接受9个月治疗的患者中，每周2次给药方案的74例中只有1例在6至9个月之间出现细菌学复发。化疗6个月后随访的前6个月，每日给药方案的细菌学复发率为13%，每周3次给药方案为16%，每周2次给药方案为18%；化疗9个月后，复发率分别为3%、4%和4%。所有33例复发均为对异烟肼和链霉素敏感的菌株，其中76%发生在化疗结束后的前3个月。虽然预处理为耐药菌株的患者情况较差，但约三分之二的患者在6个月时细菌学状态良好，所有3种9个月疗程的复发率都很低。对这些研究结果的意义进行了讨论。
