质子泵抑制剂雷贝拉唑及其硫醚衍生物对幽门螺杆菌运动性的新作用。
A novel action of the proton pump inhibitor rabeprazole and its thioether derivative against the motility of Helicobacter pylori.
作者信息
Tsutsui N, Taneike I, Ohara T, Goshi S, Kojio S, Iwakura N, Matsumaru H, Wakisaka-Saito N, Zhang H M, Yamamoto T
机构信息
Department of Bacteriology, School of Medicine, Niigata University, 757 Ichibanchou, Niigata, Japan.
出版信息
Antimicrob Agents Chemother. 2000 Nov;44(11):3069-73. doi: 10.1128/AAC.44.11.3069-3073.2000.
The motility of Helicobacter pylori was maximum at 37 degrees C and at pH 6. A newly developed proton pump inhibitor, rabeprazole (RPZ), and its thioether derivative (RPZ-TH) markedly inhibited the motility of H. pylori. The concentrations of the drug necessary to inhibit 50% of the motility were 0.25, 16, 16, and >64 microgram/ml for RPZ-TH, RPZ, lansoprazole, and omeprazole, respectively. No such inhibitory effects were observed with H(2) blockers or anti-H. pylori agents. The motilities of Campylobacter jejuni and C. coli-but not those of Vibrio cholerae O1 and O139, Vibrio parahaemolyticus, Salmonella enterica serovar Typhimurium, and Proteus mirabilis-were also inhibited. Prolonged incubation with RPZ or RPZ-TH inhibited bacterial growth of only H. pylori, except for a turbid colony mutant. The results indicate that RPZ and RPZ-TH have a characteristic inhibitory effect against the motility of H. pylori (spiral-shaped bacteria), which is distinguished from that against bacterial growth.
幽门螺杆菌的运动性在37摄氏度和pH值为6时最强。一种新开发的质子泵抑制剂雷贝拉唑（RPZ）及其硫醚衍生物（RPZ-TH）显著抑制幽门螺杆菌的运动性。抑制50%运动性所需的药物浓度，RPZ-TH、RPZ、兰索拉唑和奥美拉唑分别为0.25、16、16和>64微克/毫升。H2受体阻滞剂或抗幽门螺杆菌药物未观察到此类抑制作用。空肠弯曲菌和大肠弯曲菌的运动性——但霍乱弧菌O1和O139、副溶血性弧菌、肠炎沙门氏菌鼠伤寒血清型和奇异变形杆菌的运动性未受抑制——也受到抑制。用RPZ或RPZ-TH长时间孵育仅抑制幽门螺杆菌的细菌生长，但有一种浑浊菌落突变体除外。结果表明，RPZ和RPZ-TH对幽门螺杆菌（螺旋形细菌）的运动性具有特征性抑制作用，这与对细菌生长的抑制作用不同。
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