Hirayama F, Takagi S, Iwao E, Yokoyama Y, Haga K, Hanada S
Pharmaceutical Research Division, Yoshitomi Pharmaceutical Industries, Chikujo, Fukuoka, Japan.
J Gastroenterol. 1999 Aug;34(4):450-4. doi: 10.1007/s005350050295.
A Mongolian gerbil model was used to clarify whether long-term colonization by Helicobacter pylori is an important risk factor for the development of gastric cancer. Fifty-nine gerbils (3 controls and 56 gerbils inoculated with H. pylori) were killed at various times (average, 23 months) more than 12 months after H. pylori inoculation. In the H. pylori-inoculated group, poorly differentiated adenocarcinoma was observed in the pylorus of 1 gerbil, and carcinoid was observed in the fundus of the stomach in 18 gerbils. No lesions were found in the stomachs of the 3 control gerbils. The results imply that long-term colonization by H. pylori is an important risk factor for the development of gastric adenocarcinoma and carcinoid.
采用蒙古沙鼠模型来阐明幽门螺杆菌的长期定植是否是胃癌发生的重要危险因素。在接种幽门螺杆菌12个月以上的不同时间点（平均23个月）处死了59只沙鼠（3只对照沙鼠和56只接种幽门螺杆菌的沙鼠）。在接种幽门螺杆菌的组中，在1只沙鼠的幽门处观察到低分化腺癌，在18只沙鼠的胃底观察到类癌。3只对照沙鼠的胃中未发现病变。结果表明，幽门螺杆菌的长期定植是胃腺癌和类癌发生的重要危险因素。
