美罗培南对革兰氏阳性和革兰氏阴性菌株的抗生素后白细胞增强作用。
Postantibiotic leukocyte enhancement of meropenem against gram-positive and gram-negative strains.
作者信息
Novelli A, Fallani S, Cassetta M I, Conti S, Mazzei T
机构信息
Dipartimento di Farmacologia Preclinica e Clinica, Università degli Studi di Firenze, Florence, Italy.
出版信息
Antimicrob Agents Chemother. 2000 Nov;44(11):3174-6. doi: 10.1128/AAC.44.11.3174-3176.2000.
Abstract
The postantibiotic leukocyte enhancement (PALE) of meropenem in vitro in comparison with that of imipenem was evaluated with 24 recently isolated gram-positive and gram-negative strains. In general, pre-exposure to carbapenems (at four times the MIC for 2 h) led to increased polymorphonuclear cell phagocytic killing. The PALE of imipenem was generally significantly less than that observed with meropenem.
摘要
使用24株最近分离出的革兰氏阳性和革兰氏阴性菌株，评估了美罗培南与亚胺培南相比的体外抗生素后白细胞增强（PALE）作用。一般来说，预先暴露于碳青霉烯类药物（在最低抑菌浓度的4倍下作用2小时）会导致多形核细胞吞噬杀伤作用增强。亚胺培南的PALE通常明显低于美罗培南。
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