亚胺培南对铜绿假单胞菌的抗生素后效应。
Postantibiotic effect of imipenem on Pseudomonas aeruginosa.
作者信息
Bustamante C I, Drusano G L, Tatem B A, Standiford H C
出版信息
Antimicrob Agents Chemother. 1984 Nov;26(5):678-82. doi: 10.1128/AAC.26.5.678.
Abstract
Imipenem (formerly N-formimidoyl thienamycin) and ceftazidime were investigated for their postantibiotic effect on Pseudomonas aeruginosa. Four strains of P. aeruginosa in the logarithmic phase of growth were exposed for 1 and 2 h to concentrations of antibiotics achievable in human serum. Recovery periods of test cultures were evaluated after dilution or addition of beta-lactamase. A consistent postantibiotic effect against all strains was obtained with imipenem but not with ceftazidime. Although ceftazidime did not have a postantibiotic effect, it did suppress the growth of the organisms at concentrations equivalent to one-third of the MIC. The clinical implications of these effects need further evaluation.
摘要
研究了亚胺培南（原名N-甲酰亚胺硫霉素）和头孢他啶对铜绿假单胞菌的抗生素后效应。将处于对数生长期的4株铜绿假单胞菌暴露于在人血清中可达到的抗生素浓度下1小时和2小时。在稀释或添加β-内酰胺酶后评估试验培养物的恢复期。亚胺培南对所有菌株均获得了一致的抗生素后效应，而头孢他啶则没有。虽然头孢他啶没有抗生素后效应，但它在相当于最低抑菌浓度三分之一的浓度下确实抑制了细菌的生长。这些效应的临床意义需要进一步评估。
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