Barnes T R, Hutton S B, Chapman M J, Mutsatsa S, Puri B K, Joyce E M
Department of Psychiatry, Imperial College School of Medicine, London.
Br J Psychiatry. 2000 Sep;177:207-11. doi: 10.1192/bjp.177.3.207.
Studies in schizophrenia suggest that a longer initial period of untreated illness is associated with a poorer clinical outcome.
To determine whether, in first-episode schizophrenia, a longer duration of untreated psychosis (DUP) or of untreated illness (DUI) (DUP plus any prodrome) is associated with clinical variables that could mediate a poor prognosis.
Clinical, social, neuropsychological and oculomotor function data on 53 patients with first-episode schizophrenia were related to the DUP and DUI.
Comparing short and long DUP groups split around the median showed no statistically significant differences (except age); patients in the latter group tended to perform worse on an executive attentional set-shifting task, and were more likely to be unemployed, and living alone or homeless.
There was little evidence of any association between either DUP or DUI and progressive deterioration in the schizophrenic illness or the development of resistance to initial drug treatment. Social variables that augur a poor prognosis may be associated with delayed presentation of schizophrenia to psychiatric services.
对精神分裂症的研究表明，疾病未治疗的初始阶段较长与较差的临床结局相关。
确定在首发精神分裂症中，较长的未治疗精神病持续时间（DUP）或未治疗疾病持续时间（DUI）（DUP加上任何前驱期）是否与可能介导不良预后的临床变量相关。
对53例首发精神分裂症患者的临床、社会、神经心理学和眼动功能数据与DUP和DUI进行关联分析。
比较以中位数划分的短DUP组和长DUP组，未发现统计学上的显著差异（年龄除外）；后一组患者在执行性注意力转换任务上的表现往往较差，更有可能失业，独居或无家可归。
几乎没有证据表明DUP或DUI与精神分裂症病情的进行性恶化或对初始药物治疗产生耐药性之间存在任何关联。预示不良预后的社会变量可能与精神分裂症患者延迟就医有关。
