Walker M P, Ayre G A, Cummings J L, Wesnes K, McKeith I G, O'Brien J T, Ballard C G
Medical Research Council, Neurochemical Pathology Unit, Newcastle upon Tyne, UK.
Br J Psychiatry. 2000 Sep;177:252-6. doi: 10.1192/bjp.177.3.252.
The identification of fluctuating confusion is central to improving the differential diagnosis of the common dementias.
To determine the value of two rating scales to measure fluctuating confusion.
The agreement between the clinician-rated scale and the scale completed by a non-clinician was determined. Correlations between the two scales were calculated; variability in attention was calculated on a computerised cognitive assessment and variability in delta rhythm on an electroencephalogram (EEG).
The Clinician Assessment of Fluctuation and the computerised cognitive assessment were completed for 155 patients (61 Alzheimer's disease, 37 dementia with Lewy bodies, 22 vascular dementia, 35 elderly controls). A subgroup (n = 40) received a further evaluation using the One Day Fluctuation Assessment Scale and an EEG. The two scales correlated significantly with each other, and with the neuropsychological and electrophysiological measures of fluctuation.
Both scales are useful instruments for the clinical assessment of fluctuation in dementia.
识别波动性认知障碍对于改善常见痴呆症的鉴别诊断至关重要。
确定两种评定量表在测量波动性认知障碍方面的价值。
确定临床医生评定量表与非临床医生完成的量表之间的一致性。计算两种量表之间的相关性；通过计算机化认知评估计算注意力的变异性，并通过脑电图（EEG）计算δ波节律的变异性。
对155例患者（61例阿尔茨海默病、37例路易体痴呆、22例血管性痴呆、35例老年对照）完成了波动性临床评估和计算机化认知评估。一个亚组（n = 40）使用一日波动性评估量表和脑电图进行了进一步评估。两种量表相互之间以及与波动性的神经心理学和电生理测量均显著相关。
两种量表都是用于痴呆症波动性临床评估的有用工具。
