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二肉豆蔻酰磷脂酰胆碱脂质体对体内癌小鼠模型具有显著治疗效果。

Marked therapeutic effect of dimyristoylphosphatidylcholine liposomes on carcinoma mice model in vivo.

作者信息

Ueoka R, Matsumoto Y, Kanno A, Tsuzaki K, Ichihara H

机构信息

Graduate Course of Applied Chemistry, Sojo University Kumamoto, Japan.

出版信息

Biol Pharm Bull. 2000 Oct;23(10):1262-3. doi: 10.1248/bpb.23.1262.

Abstract

Significantly prolonged survival rate was obtained for the first time using carcinoma mice models after the administration of single-component liposomes of dimyristoylphosphatidylcholine (DMPC) without any drug. An increase in lymphocytes under optical microscope was observed without any increase in the neutrophils count, suggesting that the DMPC liposomes might inhibit the tumor growth as well as increase in lymphocytes in vivo.

摘要

在未使用任何药物的情况下,首次使用二肉豆蔻酰磷脂酰胆碱(DMPC)单组分脂质体处理癌小鼠模型后,获得了显著延长的存活率。光学显微镜下观察到淋巴细胞增加,而中性粒细胞计数未增加,这表明DMPC脂质体可能在体内抑制肿瘤生长并增加淋巴细胞数量。

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