用于黑素沉着病的混合脂质体化疗
Chemotherapy with hybrid liposomes for melanomatosis.
作者信息
Kanno A, Tsuzaki K, Miyagi M, Matsumoto Y, Ueoka R
机构信息
Graduate Course of Applied Chemistry, Kumamoto Institute of Technology, Japan.
出版信息
Biol Pharm Bull. 1999 Sep;22(9):1013-4. doi: 10.1248/bpb.22.1013.
The inhibitory effects of the hybrid liposomes on the growth of B-16 melanoma cells in vitro and in vivo were examined. The 50% inhibitory concentration of the hybrid liposomes composed of 90 mol% dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylenedodecyl ether (C12(EO)10) was one-twelfth of that of DMPC liposomes. It was noteworthy that for the first time significantly prolonged survival was obtained using a mouce model of carcinoma after the administration of the hybrid liposomes of 90 mol% DMPC/10 mol% C12(EO)n (n=10 or 23) without antitumor drugs.
研究了杂化脂质体对B - 16黑色素瘤细胞体外和体内生长的抑制作用。由90摩尔%二肉豆蔻酰磷脂酰胆碱（DMPC）和10摩尔%聚氧乙烯十二烷基醚（C12(EO)10）组成的杂化脂质体的50%抑制浓度是DMPC脂质体的十二分之一。值得注意的是，在没有抗肿瘤药物的情况下，使用90摩尔%DMPC/10摩尔%C12(EO)n（n = 10或23）的杂化脂质体给药后，首次在小鼠癌模型中获得了显著延长的生存期。
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