van Loon G, Tavernier R, Duytschaever M, Fonteyne W, Deprez P, Jordaens L
Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, University of Ghent, Merelbeke, Belgium.
Can J Vet Res. 2000 Oct;64(4):254-8.
A transvenous, screw-in electrode was implanted in the right atrium of a healthy pony and connected with an implantable pulse generator programmed to deliver bursts of electrical stimuli to the atrium. Initially, cessation of burst pacing resulted in short (less than 1 minute), self-terminating episodes of atrial fibrillation. As burst pacing continued, the episodes of induced atrial fibrillation became longer. After 3 weeks of continuous atrial pacing, atrial fibrillation became sustained (56 hours). This model of pacing induced atrial fibrillation can be used to study the mechanisms leading to atrial fibrillation, its perpetuation and therapy. Our preliminary observations support the concept that once atrial fibrillation starts, it sets up changes in the electrical characteristics of the atrium that favor its own perpetuation.
将一根经静脉拧入式电极植入一匹健康小马的右心房，并与一个可植入式脉冲发生器相连，该脉冲发生器被设定为向心房输送电刺激脉冲串。最初，停止脉冲串起搏会导致短暂（少于1分钟）、自行终止的房颤发作。随着脉冲串起搏的持续，诱发的房颤发作时间变长。持续心房起搏3周后，房颤持续发作（56小时）。这种起搏诱发房颤的模型可用于研究导致房颤、其持续存在及治疗的机制。我们的初步观察结果支持这样一种概念，即一旦房颤开始，它会引起心房电特性的改变，从而有利于其自身的持续存在。
