Wogan G N
Cancer Res. 1975 Nov;35(11 Pt. 2):3499-502.
Incidence patterns of primary liver cancer in Swaziland and Uganda have been compared with frequency of contamination of dietary staples by aflatoxins. Geographical regions or tribal groups with elevated cancer incidence were associated with increased frequency of contamination. In further studies, aflatoxin ingestion has been quantitatively measured in populations in Thailand, Kenya, and Mozambique, in subgroups of which the incidence of primary liver cancer varied over a wide range. In each instance, elevated cancer incidence was associated with highest levels of aflatoxin intake. In view of the potency of these compounds as liver carcinogens in many animal species, these data collectively suggest that the aflatoxins are also carcinogenic for man and that regular ingestion of foods heavily contaminated with aflatoxins increases the risk of liver cancer in human populations.
斯威士兰和乌干达原发性肝癌的发病模式已与黄曲霉毒素对主食的污染频率进行了比较。癌症发病率升高的地理区域或部落群体与污染频率增加有关。在进一步的研究中，对泰国、肯尼亚和莫桑比克人群的黄曲霉毒素摄入量进行了定量测量，其中原发性肝癌发病率在不同亚组中有很大差异。在每种情况下，癌症发病率升高都与黄曲霉毒素摄入量最高有关。鉴于这些化合物在许多动物物种中作为肝脏致癌物的效力，这些数据共同表明黄曲霉毒素对人类也具有致癌性，并且经常食用受黄曲霉毒素严重污染的食物会增加人群患肝癌的风险。
