甲硫米特对人体胃部的影响。
Effects of metiamide on the human stomach.
作者信息
Thjodleifsson B, Wormsley K G
出版信息
Clin Sci Mol Med. 1975 Nov;49(5):445-58. doi: 10.1042/cs0490445.
PMID:1104245
Abstract
- The effect of metiamide on gastric acidity in man has been studied. Solutions of hydrochloric acid or glucose were instilled into the stomach and the subsequent rates of gastric secretion and emptying, and the disappearance of acid within the stomach, were measured. 2. Metiamide inhibited the gastric secretory response to the instilled acid and glucose solutions but did not change the overall pattern of emptying of the instilled solutions. 3. During administration of metiamide, there was a net loss of acid from within the gastric lumen. The rate of disappearance of acid from the instilled acid solution was small and not sufficient in magnitude to account for the metiamide-evoked decrease in the concentration of acid secreted in response to pentagastrin. 4. We conclude that metiamide does not inhibit gastric secretion by altering the 'barrier' function of the gastric mucosa.
摘要
- 已对甲硫米特对人体胃酸度的影响进行了研究。将盐酸溶液或葡萄糖溶液灌入胃内，随后测量胃分泌和排空的速率，以及胃内酸的消失情况。2. 甲硫米特抑制了对灌入的酸溶液和葡萄糖溶液的胃分泌反应，但未改变灌入溶液的总体排空模式。3. 在给予甲硫米特期间，胃腔内酸出现净损失。从灌入的酸溶液中酸消失的速率较小，其幅度不足以解释甲硫米特引起的对五肽胃泌素分泌的酸浓度降低。4. 我们得出结论，甲硫米特不是通过改变胃黏膜的“屏障”功能来抑制胃分泌的。
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