布立马胺和甲硫米特对猫基础胃功能的影响。
The effects of burimamide and metiamide on basal gastric function in the cat.
作者信息
Harris D W, Smy J R, Reed J D, Venables C W
出版信息
Br J Pharmacol. 1975 Feb;53(2):293-7. doi: 10.1111/j.1476-5381.1975.tb07361.x.
Abstract
1 Burimamide injected intravenously in the anaesthetized or conscious cat produced significant increases in gastric acid secretion: in the anaesthetized cat it produced increased gastric mucosal blood flow. 2 Metiamide, in doses which inhibited pentagastrin-stimulated acid secretion, produced no increase in gastric acid secretion in conscious animals, or gastric acid secretion or gastric mucosal blood flow in the anaesthetized cat. 3 Metiamide did not influence the amount of acid which diffused out of the stomach when instilled at pH values between 1.5 and 6.0. 4 The possible mode of action of burimamide in increasing basal gastric secretion is discussed.
摘要
- 在麻醉或清醒的猫身上静脉注射甲氰咪胍，会使胃酸分泌显著增加：在麻醉猫身上，它会使胃黏膜血流量增加。2. 甲硫咪特在抑制五肽胃泌素刺激的胃酸分泌的剂量下，对清醒动物的胃酸分泌没有增加作用，对麻醉猫的胃酸分泌或胃黏膜血流量也没有增加作用。3. 当在pH值为1.5至6.0之间滴注时，甲硫咪特不影响从胃中扩散出的酸量。4. 讨论了甲氰咪胍增加基础胃分泌的可能作用方式。
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