甲硫米特对人五肽胃泌素刺激的胃酸和胃蛋白酶基础分泌的影响的相关方面。
Aspects of the effect of metiamide on pentagastrin-stimulated and basal gastric secretion of acid and pepsin in man.
作者信息
Thjodleifsson B, Wormsley K G
出版信息
Gut. 1975 Jul;16(7):501-8. doi: 10.1136/gut.16.7.501.
Abstract
This study has examined the inhibition produced by metiamide on the gastric secretion of acid and pepsin in 13 patients with duodenal and three with gastric ulcer. The effect of metiamide on the response to a range of doses of pentagastrin in three normal individuals was determined, as was the interaction of metiamide and atropine on prolonged basal secretion. Metiamide inhibited the secretion of acid more than pepsin and the gastric secretion of patients with gastric ulcer more than duodenal ulcer. Metiamide inhibited both the maximal secretory response attainable with pentagastrin and decreased the sensitivity to pentagastrin. Atropine augmented and prolonged the action of metiamide.
摘要
本研究检测了甲硫米特对13例十二指肠溃疡患者和3例胃溃疡患者胃酸及胃蛋白酶分泌的抑制作用。测定了甲硫米特对3名正常个体对不同剂量五肽胃泌素反应的影响，以及甲硫米特与阿托品对基础分泌延长的相互作用。甲硫米特对胃酸分泌的抑制作用强于胃蛋白酶，对胃溃疡患者胃分泌的抑制作用强于十二指肠溃疡患者。甲硫米特既抑制了五肽胃泌素所能达到的最大分泌反应，又降低了对五肽胃泌素的敏感性。阿托品增强并延长了甲硫米特的作用。
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