重组嵌合呼吸道合胞病毒FG糖蛋白疫苗在棉鼠体内的有效性和安全性研究。
Efficacy and safety studies of a recombinant chimeric respiratory syncytial virus FG glycoprotein vaccine in cotton rats.
作者信息
Prince G A, Capiau C, Deschamps M, Fabry L, Garçon N, Gheysen D, Prieels J P, Thiry G, Van Opstal O, Porter D D
机构信息
Virion Systems, Inc., Rockville, Maryland 20850, USA.
出版信息
J Virol. 2000 Nov;74(22):10287-92. doi: 10.1128/jvi.74.22.10287-10292.2000.
Abstract
Several formulations of a recombinant chimeric respiratory syncytial virus (RSV) vaccine consisting of the extramembrane domains of the F and G glycoproteins (FG) were tested in cotton rats to evaluate efficacy and safety. The FG vaccine was highly immunogenic, providing nearly complete resistance to pulmonary infection at doses as low as 25 ng in spite of inducing relatively low levels of serum neutralizing antibody at low vaccine doses. Upon RSV challenge animals primed with FG vaccine showed quite mild alveolitis and interstitial pneumonitis, which were eliminated by the addition of monophosphoryl lipid A to the formulation.
摘要
对由F和G糖蛋白（FG）的膜外结构域组成的重组嵌合呼吸道合胞病毒（RSV）疫苗的几种配方在棉鼠中进行了测试，以评估其有效性和安全性。FG疫苗具有高度免疫原性，尽管在低疫苗剂量下诱导的血清中和抗体水平相对较低，但在低至25 ng的剂量下就能提供几乎完全的肺部感染抗性。在用RSV攻击后，用FG疫苗免疫的动物表现出相当轻微的肺泡炎和间质性肺炎，通过在配方中添加单磷酰脂质A可消除这些症状。
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