呼吸道合胞病毒疫苗的研发。
Respiratory syncytial virus vaccine development.
机构信息
Department of Infectious Diseases, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
出版信息
Expert Rev Vaccines. 2011 Oct;10(10):1415-33. doi: 10.1586/erv.11.120.
Abstract
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract viral disease in infants and young children. Presently, there are no explicit recommendations for RSV treatment apart from supportive care. The virus is therefore responsible for an estimated 160,000 deaths per year worldwide. Despite half a century of dedicated research, there remains no licensed vaccine product. Herein are described past and current efforts to harness innate and adaptive immune potentials to combat RSV. A plethora of candidate vaccine products and strategies are reviewed. The development of a successful RSV vaccine may ultimately stem from attention to historical lessons, in concert with an integral partnering of immunology and virology research fields.
摘要
呼吸道合胞病毒（RSV）是导致婴儿和幼儿下呼吸道病毒病的主要原因。目前，除了支持性护理外，尚无针对 RSV 治疗的明确建议。因此，该病毒每年在全球造成约 16 万人死亡。尽管经过半个世纪的专门研究，但仍没有获得许可的疫苗产品。本文描述了过去和现在利用先天和适应性免疫潜力来对抗 RSV 的努力。本文回顾了大量候选疫苗产品和策略。成功 RSV 疫苗的开发最终可能源于对历史教训的关注，同时免疫学和病毒学研究领域的紧密合作。
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本文引用的文献
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