尿抑胃素在佐林格-埃利森综合征中的作用。

Effect of urogastrone in the Zollinger-Ellison syndrome.

作者信息

Elder J B, Gillespie I E, Ganguli P C, Delamore W I, Gregory H

出版信息

Lancet. 1975 Sep 6;2(7932):424-7. doi: 10.1016/s0140-6736(75)90842-9.

Abstract

The effects of human urogastrone (0-25 mug. per kg. per hour intravenously) in four male patients with proven Zollinger-Ellison syndrome (z.e.s.) and in four healthy control subjects have been studied. After urogastrone in z.e.s. patients gastric acid volume and concentration decreased and basal acid output was reduced by 50-82%; the concentrations of intrinsic factor and pepsin in gastric juice increased by 60-300%; and peak plasma-gastrin concentration increased by 127-164% of basal concentration. A significant negative correlation between increase in plasma-gastrin concentration and decrease in acid output was observed (r=-0-72, P less than 0-01). Ulcer pain was relieved 30-60 minutes after the beginning of urogastrone infusion. These results suggest that urogastrone can inhibit the endogenously stimulated acid hypersecretion in z.e.s.

摘要

研究了人尿抑胃素（静脉注射，每千克每小时0 - 25微克）对4例确诊为佐林格 - 埃利森综合征（Z.E.S.）的男性患者及4名健康对照者的影响。给Z.E.S.患者注射尿抑胃素后，胃酸分泌量和浓度降低，基础胃酸排出量减少50 - 82%；胃液中内因子和胃蛋白酶浓度升高60 - 300%；血浆胃泌素峰值浓度升高至基础浓度的127 - 164%。观察到血浆胃泌素浓度升高与胃酸排出量减少之间存在显著负相关（r = -0.72，P < 0.01）。尿抑胃素输注开始后30 - 60分钟，溃疡疼痛缓解。这些结果表明，尿抑胃素可抑制Z.E.S.患者内源性刺激引起的胃酸分泌过多。