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Porcine reproductive and respiratory syndrome virus: description of persistence in individual pigs upon experimental infection.猪繁殖与呼吸综合征病毒：实验感染后个体猪体内持续性的描述。
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本文引用的文献

1
The evolution of porcine reproductive and respiratory syndrome virus: quasispecies and emergence of a virus subpopulation during infection of pigs with VR-2332.猪繁殖与呼吸综合征病毒的进化：用VR - 2332感染猪期间的准种及病毒亚群的出现
Virology. 1999 Jul 5;259(2):262-6. doi: 10.1006/viro.1999.9789.
2
Genetic divergence with emergence of novel phenotypic variants of equine arteritis virus during persistent infection of stallions.种公马持续性感染期间马动脉炎病毒新表型变体出现时的遗传分化。
J Virol. 1999 May;73(5):3672-81. doi: 10.1128/JVI.73.5.3672-3681.1999.
3
T cell responses to the structural polypeptides of porcine reproductive and respiratory syndrome virus.T细胞对猪繁殖与呼吸综合征病毒结构多肽的应答。
Arch Virol. 1999;144(1):117-34. doi: 10.1007/s007050050489.
4
North American and European porcine reproductive and respiratory syndrome viruses differ in non-structural protein coding regions.北美和欧洲的猪繁殖与呼吸综合征病毒在非结构蛋白编码区存在差异。
J Gen Virol. 1999 Feb;80 ( Pt 2):307-315. doi: 10.1099/0022-1317-80-2-307.
5
Molecular variation in the nucleoprotein gene (ORF7) of the porcine reproductive and respiratory syndrome virus (PRRSV).猪繁殖与呼吸综合征病毒（PRRSV）核蛋白基因（ORF7）的分子变异
Virus Res. 1998 Mar;54(1):9-21. doi: 10.1016/s0168-1702(97)00146-9.
6
RNA virus mutations and fitness for survival.RNA病毒突变与生存适应性
Annu Rev Microbiol. 1997;51:151-78. doi: 10.1146/annurev.micro.51.1.151.
7
Porcine reproductive and respiratory syndrome virus: a persistent infection.猪繁殖与呼吸综合征病毒：一种持续性感染。
Vet Microbiol. 1997 Apr;55(1-4):231-40. doi: 10.1016/s0378-1135(96)01337-5.
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Antigenic variability of porcine reproductive and respiratory syndrome (PRRS) virus isolates. Influence of virus passage in pig.
Vet Res. 1997 May-Jun;28(3):247-57.
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A nested set of six or seven subgenomic mRNAs is formed in cells infected with different isolates of porcine reproductive and respiratory syndrome virus.
J Gen Virol. 1996 Jun;77 ( Pt 6):1265-70. doi: 10.1099/0022-1317-77-6-1265.
10
Enhanced replication of porcine reproductive and respiratory syndrome (PRRS) virus in a homogeneous subpopulation of MA-104 cell line.猪繁殖与呼吸综合征（PRRS）病毒在MA - 104细胞系的一个同质亚群中的复制增强。
Arch Virol. 1993;133(3-4):477-83. doi: 10.1007/BF01313785.

猪繁殖与呼吸综合征病毒：实验感染后个体猪体内持续性的描述。

Porcine reproductive and respiratory syndrome virus: description of persistence in individual pigs upon experimental infection.

作者信息

Allende R, Laegreid W W, Kutish G F, Galeota J A, Wills R W, Osorio F A

机构信息

Department of Veterinary and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska 68583-0905, USA.

出版信息

J Virol. 2000 Nov;74(22):10834-7. doi: 10.1128/jvi.74.22.10834-10837.2000.

DOI:10.1128/jvi.74.22.10834-10837.2000
PMID:11044133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC110963/
Abstract

We studied the persistence of porcine reproductive and respiratory syndrome virus (PRRSV) in individual experimentally infected pigs, during a period of up to 150 days postinfection (dpi). The results of this study suggest that the persistence of PRRSV involves continuous viral replication but that it is not a true steady-state persistent infection. The virus eventually clears the body and seems to do it in most of the animals by 150 dpi or shortly thereafter. High genetic stability was seen for several regions of the persistent PRRSV's genome, although some consistent mutations in the genes of envelope glycoproteins and M protein were also observed.

摘要

我们研究了猪繁殖与呼吸综合征病毒（PRRSV）在实验性感染的个体猪体内的持续性，感染后长达150天（dpi）。本研究结果表明，PRRSV的持续性涉及病毒的持续复制，但并非真正的稳态持续性感染。该病毒最终会清除出体内，并且在大多数动物中似乎在150 dpi或之后不久就会清除。尽管在包膜糖蛋白和M蛋白基因中也观察到一些一致的突变，但持续性PRRSV基因组的几个区域具有高度的遗传稳定性。