Paynter S J
Department of Obstetrics and Gynaecology, University of Wales College of Medicine, Cardiff, UK.
Hum Reprod Update. 2000 Sep-Oct;6(5):449-56. doi: 10.1093/humupd/6.5.449.
Cryopreservation facilitates the long-term storage of oocytes from patients in danger of losing ovarian function and allows greater flexibility in fertility services for other patients. If some of the oocytes collected following ovulation stimulation are stored prior to fertilization, this alleviates many of the ethical concerns associated with embryo preservation. Concerns that cryopreservation could lead to disruption of the spindle and chromosomes, thus leading to genetic abnormalities of the offspring produced, mean that this procedure is not permitted in some countries. The recent spate of human live births from thawed oocytes has prompted the granting of the first licence allowing the use of thawed oocytes in the UK. However, the success rate of this procedure is still low and further research is required to refine these techniques and to develop new ones.
冷冻保存有助于长期储存面临卵巢功能丧失风险患者的卵母细胞，并为其他患者的生育服务提供更大的灵活性。如果在排卵刺激后收集的一些卵母细胞在受精前储存起来，这将减轻许多与胚胎保存相关的伦理问题。担心冷冻保存可能导致纺锤体和染色体破坏，从而导致所产生后代的基因异常，这意味着在一些国家不允许进行此操作。最近解冻卵母细胞诞生人类活体婴儿的情况促使英国首次颁发许可证，允许使用解冻的卵母细胞。然而，该程序的成功率仍然很低，需要进一步研究来完善这些技术并开发新的技术。
