Mor-Avi V, Spencer K, Gorcsan J, Demaria A, Kimball T, Monaghan M, Perez J, Sun J P, Weinert L, Bednarz J, Collins K, Edelman K, Kwan O L, Glascock B, Hancock J, Baumann C, Thomas J, Lang R
The University of Chicago, Chicago, Illinois 60637, USA.
Am J Physiol Heart Circ Physiol. 2000 Nov;279(5):H2464-76. doi: 10.1152/ajpheart.2000.279.5.H2464.
Our goal was to establish normal values for quantitative color kinesis indexes of left ventricular (LV) wall motion over a wide range of ages, which are required for objective diagnosis of regional systolic and diastolic dysfunction. Color-encoded images were obtained in 194 normal subjects (95 males, 99 females, age 2 mo to 79 yr) in four standard views. Quantitative indexes of magnitude and timing of systolic and diastolic function were studied for age- and gender-related differences. Normal limits of all ejection and filling indexes were in a narrow range (< or =25% of the mean), with no major gender-related differences. Despite invariable ejection fractions, both peak filling and ejection rates decreased with age (30 and 20%, correspondingly) with a concomitant increase in mean filling and ejection times, resulting in five- and twofold increases in the late to early filling and ejection ratios, correspondingly. Diastolic asynchrony increased with age (from 4.7 +/- 2.0 to 6.4 +/- 3.2 from the 2nd to 7th decade). The normal values of color kinesis indexes should allow objective detection of regional LV systolic and diastolic dysfunction.
我们的目标是建立广泛年龄范围内左心室（LV）壁运动的定量彩色室壁运动分析指数的正常值，这是客观诊断局部收缩和舒张功能障碍所必需的。在194名正常受试者（95名男性，99名女性，年龄2个月至79岁）的四个标准视图中获取了彩色编码图像。研究了收缩和舒张功能的幅度和时间的定量指标与年龄和性别的差异。所有射血和充盈指数的正常范围都很窄（≤平均值的25%），没有明显的性别相关差异。尽管射血分数不变，但峰值充盈率和射血率均随年龄增长而下降（分别下降30%和20%），同时平均充盈时间和射血时间增加，导致晚期与早期充盈和射血比值分别增加了五倍和两倍。舒张不同步随年龄增长而增加（从第二个十年到第七个十年，从4.7±2.0增加到6.4±3.2）。彩色室壁运动分析指数的正常值应有助于客观检测局部左心室收缩和舒张功能障碍。
